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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Důležitost systemické inzulínové rezistence pro imunitní odpověď
 STRYCH, Lukáš
The aim of this thesis was to study insulin resistance in larval peripheral tissues of Drosophila melanogaster upon the infection by parasitoid wasp Leptopilina boulardi. Firstly, the state of the insulin signalling during the immune response was analysed by measuring gene expression and phosphorylation of Akt. Subsequently, the importance of insulin resistance in peripheral tissues for the effectivity of the immune response was tested. The effect of Jak-Stat signalling on inducing insulin resistance in larval muscle was evaluated as well.
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Characterization of metabolic changes in hemocytes during the immune response in \kur{D. melanogaster}
 KREJČOVÁ, Gabriela
The aim of this thesis is to characterize metabolic changes in hemocytes during the immune response in D. melanogaster using in vivo markers as well as by measuring gene expression. The impact of the transcription factor HIF1 on the gene expression of glycolytic enzymes and its impact on the systemic metabolism was evaluated. The importance of HIF1 and LDH in the process of fighting against S. pneumoniae infection was tested as well.
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