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National Repository of Grey Literature 4 records found  Search took 0.01 seconds. 
Simulation of action potentials and membrane currents by solving Hodgkin and Huxley equations
 Bugnerová, Pavla ; Provazník, Ivo (referee) ; Chmelíková, Larisa (advisor)
The thesis deals with the analysis of the resting membrane potential and action potential mainly on the cell membrane of cardiac cells. Attention is given to the electrical schematic layout of the cell membrane and distribution of current part on the main components. The basis for the creation of a mathematical model and simulation is the differential equations of Hodgkin and Huxley. To the description them of calcium and potassium channel leakage from other models are added. The project explores the possibilities of reproducing the known development of membrane currents in two basic modes (voltage clamp and current clamp). All in user interface MATLAB GUI.
Detailed record
Simulation of electrophysiological experiments
 Kubáček, Svatopluk ; Provazník, Ivo (referee) ; Rychtárik, Milan (advisor)
Simulation of electrophysiological experiments enables to gain valuable data about bioelectrical processes occurring on isolated cells. This thesis deals with basic principals allowing the creation of bioelectrical phenomenons and measuring techniques that need to be used in order to collect information about these phenomenons. The outcome of the thesis is a programme that serves as an instrument for simulation of measuring techniques applied on Luo-Rudy model. The programme contains basic measuring techniques – current clamp and voltage clamp – providing the possibility to change basic parameters of the model. The results of this work are later compared with the accessible literature.
Detailed record
Simulation of action potentials and membrane currents by solving Hodgkin and Huxley equations
 Bugnerová, Pavla ; Provazník, Ivo (referee) ; Chmelíková, Larisa (advisor)
The thesis deals with the analysis of the resting membrane potential and action potential mainly on the cell membrane of cardiac cells. Attention is given to the electrical schematic layout of the cell membrane and distribution of current part on the main components. The basis for the creation of a mathematical model and simulation is the differential equations of Hodgkin and Huxley. To the description them of calcium and potassium channel leakage from other models are added. The project explores the possibilities of reproducing the known development of membrane currents in two basic modes (voltage clamp and current clamp). All in user interface MATLAB GUI.
Detailed record
Simulation of electrophysiological experiments
 Kubáček, Svatopluk ; Provazník, Ivo (referee) ; Rychtárik, Milan (advisor)
Simulation of electrophysiological experiments enables to gain valuable data about bioelectrical processes occurring on isolated cells. This thesis deals with basic principals allowing the creation of bioelectrical phenomenons and measuring techniques that need to be used in order to collect information about these phenomenons. The outcome of the thesis is a programme that serves as an instrument for simulation of measuring techniques applied on Luo-Rudy model. The programme contains basic measuring techniques – current clamp and voltage clamp – providing the possibility to change basic parameters of the model. The results of this work are later compared with the accessible literature.
Detailed record

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