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Determination of pharmaceuticals in drinking waters using HPLC
Králová, Radka ; Čáslavský, Josef (referee) ; Vávrová, Milada (advisor)
The aim of the diploma thesis is the determination of macrolide antibiotics in drinking water by using of high performance liquid chromatography. Erythromycin and clarithromycin were selected such as representative macrolides due to frequently prescribed pharmaceuticals in this time. Solid phase extraction (SPE) by using of Oasis HLB cartridges was applied for pre concentration and purification of chosen analytes in real samples of drinking water. Optimalization of method and analysis were performed by using of high performance liquid chromatography with mass spectrometry detection (HPLC-MS). The suitable method was selected for determination of macrolides in real samples taken from two sources of drinking water, the interception of water in Litovel and Černovír Olomouc.
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Determination of drugs by HPLC with different detectors
Benešová, Markéta ; Opatřilová, Radka (referee) ; Vávrová, Milada (advisor)
This diploma thesis deals with the determination of macrolide antibiotics in wastewater, especially with erythromycin, clarithromycin and roxithromycin. In this time are these pharmaceuticals prescribed quite frequently. Solid phase extraction (SPE) was used for the isolation and the purification of selected analytes from an aqueous matrix; as the suitable procedure was found the using Oasis HLB cartridges. High performance liquid chromatography with mass spectrometry detection (HPLC-MS) was optimized for its analysis of selected pharmaceuticals. The optimized method was used for the determination of pharmaceuticals in real water samples, which was taken at the inflow and the outflow of the urban wastewater treatment plant in Brno-Modřice.
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Determination of macrolides in wastewater during the technology applied to wastewater treatment plants
Landová, Pavlína ; Čáslavský, Josef (referee) ; Vávrová, Milada (advisor)
Diploma thesis is focused on determination of macrolide antibiotics in wastewater. Environmental contamination with drugs currently represents a major problem. To determine the level of contamination is necessary to develop the appropriate analytical techniques. From the group of macrolide antibiotics were selected four representatives: erythromycin, clarithromycin, azithromycin and roxithromycin due to their frequent use in Czech Republic. For their isolation from wastewater was selected solid phase extraction and for analysis high performance liquid chromatography with mass spectrometric detection was chosen. Under optimized conditions, the ten days analysis of wastewater from the WWTP Brno-Modřice, two days analysis of wastewater from the WWTP Mikulov and one day analysis of wastewater from WWTP of University of Veterinary and Pharmaceutical Sciences Brno was performed.
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Determination of macrolides in wastewater during the technology applied to wastewater treatment plants
Landová, Pavlína ; Čáslavský, Josef (referee) ; Vávrová, Milada (advisor)
Diploma thesis is focused on determination of macrolide antibiotics in wastewater. Environmental contamination with drugs currently represents a major problem. To determine the level of contamination is necessary to develop the appropriate analytical techniques. From the group of macrolide antibiotics were selected four representatives: erythromycin, clarithromycin, azithromycin and roxithromycin due to their frequent use in Czech Republic. For their isolation from wastewater was selected solid phase extraction and for analysis high performance liquid chromatography with mass spectrometric detection was chosen. Under optimized conditions, the ten days analysis of wastewater from the WWTP Brno-Modřice, two days analysis of wastewater from the WWTP Mikulov and one day analysis of wastewater from WWTP of University of Veterinary and Pharmaceutical Sciences Brno was performed.
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|
Determination of pharmaceuticals in drinking waters using HPLC
Králová, Radka ; Čáslavský, Josef (referee) ; Vávrová, Milada (advisor)
The aim of the diploma thesis is the determination of macrolide antibiotics in drinking water by using of high performance liquid chromatography. Erythromycin and clarithromycin were selected such as representative macrolides due to frequently prescribed pharmaceuticals in this time. Solid phase extraction (SPE) by using of Oasis HLB cartridges was applied for pre concentration and purification of chosen analytes in real samples of drinking water. Optimalization of method and analysis were performed by using of high performance liquid chromatography with mass spectrometry detection (HPLC-MS). The suitable method was selected for determination of macrolides in real samples taken from two sources of drinking water, the interception of water in Litovel and Černovír Olomouc.
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|
|
Determination of drugs by HPLC with different detectors
Benešová, Markéta ; Opatřilová, Radka (referee) ; Vávrová, Milada (advisor)
This diploma thesis deals with the determination of macrolide antibiotics in wastewater, especially with erythromycin, clarithromycin and roxithromycin. In this time are these pharmaceuticals prescribed quite frequently. Solid phase extraction (SPE) was used for the isolation and the purification of selected analytes from an aqueous matrix; as the suitable procedure was found the using Oasis HLB cartridges. High performance liquid chromatography with mass spectrometry detection (HPLC-MS) was optimized for its analysis of selected pharmaceuticals. The optimized method was used for the determination of pharmaceuticals in real water samples, which was taken at the inflow and the outflow of the urban wastewater treatment plant in Brno-Modřice.
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