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Contrast Agents for 19F-MRI
Špánek, Jiří ; Kotek, Jan (advisor) ; Hrubý, Martin (referee)
Noninvasive imaging methods, such as MRI, are one of the most used methods in today's medicine. New MRI techniques that are being developed focus on measuring 19 F nuclei or saturation transfer between 1 H nuclei signals of contrast agent (CA) and water molecule. For these purposes, it is advantageous to use complexes of paramagnetic metal ions, whose magnetic properties cause increased rate of relaxation and thus reducing acquisition time. In this bachelor thesis two new ligands L1 and L2 are prepared, whose complexes with metal ions, such as Cu2+ and Ni2+ , could find a potencial use as CAs in methods mentioned above.
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Porphyrine conjugates for MRI
Dušek, Pavel ; Vojtíšek, Pavel (advisor) ; Kotková, Zuzana (referee)
The theoretical part of this bachelor's thesis focuses on clinical applications of MRI methods. It also presents a list of gadolinium-based contrast agents used in clini- cal practice. A new conjugate of 1,4,7,10-tetraazacyclododecane-4,7,10-triacetate-1- {methyl-[(4-aminophenyl)methyl]phosphinic} acid and 5,10,15,20-tetrakis(4-amino- phenyl)porphyrin potentially active as a contrast agent is designed on the basis of this review. Due to unique properties of porphyrin unit, this compound may act as a bimodal contrast agent or contrast agent for functional imaging. The target compound and its ytterbium-complex were synthesized and partially characterized.
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The tetrathiofulvalene derivatives: Their synthesis and properties
Nejedlý, Jindřich ; Starý, Ivo (advisor) ; Hocek, Michal (referee)
The goal of the diploma thesis was to prepare a spectrum of electron-rich macrocyclic derivatives of tetrathiafulvalene (TTF), which should serve as electron donors in interactions with electron-deficient acceptor molecules. A two-step synthesis was used for their preparation. First, a non-cyclic three-segment precursor was prepared by a reaction of a thiolate TTF construction block with a bis(bromomethyl)aromate. Then, a reaction of this precursor with another molecule of bis(bromomethyl)derivative closed the macrocycle. The latter reaction produced mainly [2+2] macrocycles containing two TTF and two aromatic units. In most cases, larger [4+4] macrocycles were also isolated from the reaction mixture. Besides thiolate TTF unit two other thiolate units, one with extended TTF core and other with smaller trithiafulvene ring, were used analogically in synthesis. By a combination of three thiolate blocks and five bis(bromomethyl)aromates 11 three-segment components were prepared and these were converted to 11 structural types of macrocycles with [2+2] and 7 macrocycles with [4+4] stoichiometry. The resulting macrocycles were characterized by 1 H a 13 C NMR spectroscopy and analyzed by a gel permeation chromatography. Their structures were also confirmed by high-resolution mass spectroscopy. Interaction...
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