|
|
Analysis of 3D CT image data aimed at segmentation of bone elements and other specific tissue types
Kodym, Oldřich ; Herout, Adam (referee) ; Jan, Jiří (advisor)
The goal of this thesis is to get acquainted with methods of determining bone mineral density from appropriate tissue types in diagnostic CT data and possibly modifying or extending them in order to make the bone quality diagnosis more reliable. The thesis begins by introducing the issue of determining bone quality. Next, a method that takes cortical bone deformations into account as well as bone mineral density is introduced. Accuracy assessment based on opinion of a medical expert suggests positive outcome of future objective accuracy assessment utilizing so far unavailable base of calibrated CT data, that is needed before deployment into clinical practice. If the accuracy of the suggested method is confirmed this way, this work provides a so far absent tool for fully automatic preventive diagnostics of osteoporosis.
|
|
|
Impact of glucocorticoid treatment on musculosceletal system of pediatric patients with acute lymphoblastic leukemia.
Petráčková, Karolína ; Jevič, Filip (advisor) ; Šrámková, Lucie (referee)
This bachelor thesis aims to provide a general overview of complications of musculoskeletal system in pediatric patients diagnosed with acute lymphoblastic leukemia (ALL) undergoing chemotherapy treatment involving high cumulative doses of glucocorticoids. Musculoskeletal complications include steroid myopathy, osteonecrosis and reduced bone mineral density. The first part describes their basic pathophysiological mechanisms and the risk factors of their origin. The second part presents the current possibilities of muscle strength assessment and available exercise programs. Furthermore, diagnosis of osteonecrosis and bone mineral density are presented together with current possibilities of therapeutic intervention. The thesis also covers characteristics of muscle strength measuring methods and exercise programs along with presentation of the results of individual studies. In the discussion part, there are broken down the limits, advantages and disadvantages of using the muscle strength measuring methods and exercise programs in clinical practice.
|
|
|
Bone density in persons after spinal cord injury
Starková, Kateřina ; Coufalová, Klára (advisor) ; Šteffl, Michal (referee)
Title: Bone density in people after spinal cord injury Objective: The purpose of this paper is to determine the levels of bone mineral density in people following a spinal cord injury. The levels are measured using a DXA device and the results are subsequently evaluated. Methods: The thesis is composed of eight independent case studies. A non-standardized 14 open and closed question survey was used for quantifying purposes. Answering the questions was a necessary prerequisite for participation in the survey. The measured results of bone density and body composition were used for data analysis, together with the survey, in comparison with other studies. Results: Eight probands (four women and four men) participated in the research. Based on the obtained data, we can state that all probands (n=8) record a decrease in bone mineral density to the level of Osteopenia. Better bone mineral density measurements have not been confirmed in individuals with lower spinal cord lesions. Probands who regularly engaged in sports and daily training before spinal injuries have better results in densitometric measurements. Furthermore, it can be confirmed that probands with a past compression fracture have worse measurement results than probands without a past fracture. However, due to the low number of measured...
|
|
|
Impact of glucocorticoid treatment on musculosceletal system of pediatric patients with acute lymphoblastic leukemia.
Petráčková, Karolína ; Jevič, Filip (advisor) ; Šrámková, Lucie (referee)
This bachelor thesis aims to provide a general overview of complications of musculoskeletal system in pediatric patients diagnosed with acute lymphoblastic leukemia (ALL) undergoing chemotherapy treatment involving high cumulative doses of glucocorticoids. Musculoskeletal complications include steroid myopathy, osteonecrosis and reduced bone mineral density. The first part describes their basic pathophysiological mechanisms and the risk factors of their origin. The second part presents the current possibilities of muscle strength assessment and available exercise programs. Furthermore, diagnosis of osteonecrosis and bone mineral density are presented together with current possibilities of therapeutic intervention. The thesis also covers characteristics of muscle strength measuring methods and exercise programs along with presentation of the results of individual studies. In the discussion part, there are broken down the limits, advantages and disadvantages of using the muscle strength measuring methods and exercise programs in clinical practice.
|
|
|
Analysis of 3D CT image data aimed at segmentation of bone elements and other specific tissue types
Kodym, Oldřich ; Herout, Adam (referee) ; Jan, Jiří (advisor)
The goal of this thesis is to get acquainted with methods of determining bone mineral density from appropriate tissue types in diagnostic CT data and possibly modifying or extending them in order to make the bone quality diagnosis more reliable. The thesis begins by introducing the issue of determining bone quality. Next, a method that takes cortical bone deformations into account as well as bone mineral density is introduced. Accuracy assessment based on opinion of a medical expert suggests positive outcome of future objective accuracy assessment utilizing so far unavailable base of calibrated CT data, that is needed before deployment into clinical practice. If the accuracy of the suggested method is confirmed this way, this work provides a so far absent tool for fully automatic preventive diagnostics of osteoporosis.
|
guest ::
