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Laboratory Methods of Clostridium difficile Diagnostics in Hospitalized Patients in Tábor Hospital, a.s.
ČÍŽEK, Luboš
This thesis deals with the issue of bacterial infection caused by Clostridium difficile. This infection is a significant medical and epidemiological problem, especially in hospitalized patients in health care facilities. The theoretical part of this thesis focuses on the description of the bacterium Clostridium difficile, deals with its clinical significance, the causes of occurrence, and laboratory methods used to examine samples for the presence of the bacterium and its toxins. It summarizes current possibilities of treatment and prevention of the diseases caused by the bacterium. The practical part describes current laboratory examination procedures in the Hospital Tábor, a.s. The data from the examinations in the reference years are processed there. All analysed data describe results of examinations in patients hospitalized in the hospital in Tábor. The practical part of the thesis brings summarized and evaluated results of the examinations. This part is gives answers to the question of adequacy of examination procedures and the impact of selected risk factors on the frequency of the examinations. It also includes evidence that the incidence of health care associated Clostridium difficile colitis has been increasing over the years. The cases of two patients affected by this colitis caused by previous antibiotic treatment are also described. In conclusion, the thesis summarizes the importance of Clostridium difficile and answers to the set questions. It was found that high number of results of tested samples were negative. Therefore, possible improvements are recommended.
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Detection of circulating antibodies to determination of autoimmuno diseases by means of immunofluorescence.
Sieglová, Kateřina ; Nachtigal, Petr (advisor) ; Laco, Jan (referee)
Kateřina Sieglová Detection of circulating antibodies to determination of autoimmuno diseases by means of imunofluorescence. Bachelor thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Medical Laboratory Technician Background: The aim of this thesis is to explore of coherence between the presence of antibody against anti brush border antibody (ABBA) and idiopatic bowel disease (Crohn's disease and ulcerative colitis). Methods: Evidence of connection idiopatic bowel disease with positive ABBA test is examine by two perspectives, which are used for selecting and comparising of data. The first way is comparison of the number ABBA positive patients with their diagnosis of endoscopic biopsy. The second way check the positivity or negativity of ABBA examination of all patients with diagnose of idiopatic bowel disease. Experimental part summarize by this way the results, which was done at the Fingerland institute of pathology since 2009 to 2011. Results: The survey showed that among all the ABBA-positive patients is a large group of those who don't have the morphological signs of Inflammatory Bowel Disease - 72,47%. 66.67% of patients with a clinical diagnosis of Crohn's disease, and 39.37% of patients with ulcerative colitis are ABBA positive. Conclusion: The results shows, that...
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