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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Monoclonal gammopathies from point of view of the biochemist
 Drábková, Gabriela ; Herink, Josef (advisor) ; Kovařík, Miroslav (referee)
Gabriela Drábková Monoclonal gammopathy from the point of view of a biochemist Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Healthcare bioanalytics- Specialist in laboratory methods Monoclonal gammopathy are a very heterogeneous group of diseases characterized by the proliferation of one clone of differentiated B lymphocytes producing homogeneous immunoglobulin, the so-called monoclonal immunoglobulin. This monoclonal immunoglobulin can be detected in serum and / or urine. Monoclonal gammopathy can also be defined as a group of diseases that result from mutation in a B-cell line. The monoclonal immunoglobulin may consist of both the intact immunoglobulin molecule or the structural components, i.e., the kappa or lambda light chains, more rarely from the heavy chains of the immunoglobulin molecule. The basic investigation methods of monoclonal immunoglobulin detection include serum protein electrophoresis and immunofixation electrophoresis. Another important method in diagnosis and monitoring is the determination of free light chains. Multiple myeloma is an example of a tumor in which the prognosis has improved so much in recent years that today we can talk about a chronic illness. Median survival is currently around six years, and some patients get into...
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Pertussis, possibilities of managing unsatisfactory epidemiological situation in the Czech Republic.
 PINĎÁKOVÁ, Lucie
This thesis deals with the problems of pertussis epidemiological problems in the Czech Republic, especially the possibilities of improvement of the epidemiological situation of pertussis. Pertussis is a serious infectious disease of the respiratory system and is monitored long-term in Czech Republic. The incidence of pertussis in its epidemic cycles continues to increase since the 90s. Last year's reported sickness rate was 11.7 of 100 000 people (1233 cases total).The thesis is divided into theoretical and practical part. The theoretical part shows the characteristics of pertussis and describes the preventive and repressive measures. Last part of the theoretical section describes epidemiological situation of pertussis from history to the present day while last four years are described in more detail. The practical part of the thesis consists of research.The research was conducted using qualitative method. As data collection method was chosen interviews with first contact physicians, which are pediatricians and physicians for adults. Two objectives were set in research area. The first objective was to map the compliance with the conditions laid down under the "case" definition of pertussis and its methods of diagnosis for pediatricians and physicians for adults (first contact physicians). The second objective was to create intervention for affecting the adverse epidemiological situation of pertussis. Intervention is based on the results of research aimed at compliance with procedures of "case" definition of pertussis and on knowledge of pediatricians and physicians for adults about the epidemiology of pertussis issue and their views on vaccination.
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