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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Changes in elemental distribution of rat liver tissue associated with myocardial fibrosis using LA-ICP-MS
 Štrenclová, Eliška ; Zlámalová Gargošová, Helena (referee) ; Vašinová Galiová, Michaela (advisor)
Myocardial fibrosis is a pathological condition characterized by excessive accumulation of extracellular matrix in cardiac tissue, resulting in impaired cardiac function and potentially serious cardiovascular complications. However, recent studies suggest that myocardial fibrosis may affect not only cardiac tissue but also other organs such as the liver. The aim of this bachelor thesis was to investigate changes in the elemental distribution of liver tissue from healthy individuals by comparing the elemental distribution of liver tissue from individuals with myocardial fibrosis using the LA-ICP-MS method. When comparing the distribution maps of the control and experimental groups, changes were observed mainly in the distribution of iron isotopes; therefore, particular attention was later paid to it. The results of this research may contribute significantly to a better understanding of the relationship between myocardial fibrosis and liver tissue, and the knowledge gained may help to develop new diagnostic approaches.
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Stanovení mastných kyselin ve vybraných živočišných tkáních
 Piknerová, Tereza
My thesis consists of a theoretical part and a practical part. In theoretical part I deal with information about the fatty acids and its structure, functions and influence on our health. Last but not least I focused on diseases that may arise due to bad intake of fatty acids. It is the atherosclerosis. The second part of my thesis is the already mentioned practical part. This consisted of a samples of pigs in which were taken all animal tissues and subsequent determination of the fatty acids. In my thesis I deal with liver and muscle tissue. These samples were taken from pigs that had fish or palm oil in the diet. The determination was done by lyophilization, extraction, derivatization and gas chromatography. Based on the results, I conducted a statistical evaluation using graphs and a final evaluation of the results.
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