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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Invasive structures of cancer cells in 3D environment
 Lyková, Dominika ; Tolde, Ondřej (advisor) ; Libusová, Lenka (referee)
The ability of cells to migrate through tissue barriers plays an important role in physiological and pathological processes including immune response or invasiveness of cancer cells. The cells generate cytoplasmic protrusions called podosomes and invadopodia, collectively known as invadosomes or podosome-type adhesions (PTA), which are thought to be the key structures of cell invasion, especially of cancer cells during metastasis. Invadosomes are F-actin rich cell-matrix contacts with capability to degrade extracellular matrix components and are observed both in normal cells (such as monocytic cells, endothelial cells and smooth muscle cells) and in cancer cells. This bachelor thesis is focused on those in cancer cells, their initiation, regulation, function and morphology in 3D and in vivo and their requirement for tumor metastasis.
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