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Comprehensive evaluation of the occurrence and perception of hypoglycemia in patients with type 1 diabetes mellitus
Zadáková, Eliška ; Horová, Eva (advisor) ; Škrha, Jan (referee)
Backround: For many patients with Type 1 diabetes mellitus (T1DM), hypoglycemia is a major obstacle to achieving satisfactory compensation. Hypoglycemia unawareness is present in approximately 25 % of patients with T1DM. We use the validated Gold Score and Clarke Score questionnaires in combination with data from continuous (CGM) or instantaneous (FGM) glucose monitoring sensors to assess the perception disorder. Aims: The aim of this diploma thesis was a comprehensive assessment of the occurrence of hypoglycemia unawareness based on the validated Gold Score and Clarke Score questionnaires and the demonstration of the connection between impaired perception of hypoglycemia according to questionnaires and the percentage of time spent in hypoglycemia based on sensor data. Research methodology: In this observational and questionnaire non-interventional study, 73 patients treated with T1DM for more than 12 months and using CGM or FGM (age 41 years 16, duration of T1DM 16.7 years 11, HbA1c 52 mmol/mol 9 ,7) who completed the Gold Score, Clarke Score and HABS questionnaires to supplement the psychological level of the issue. In these patients, data from their sensors was obtained and the parameters such as average glycemia, percentage of time in the range in hypoglycemia (3.9-10 mmol/l), glycemic...
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