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Insulin resistance in the context of the ovarian cycle and PCOS
Petrásková, Karolína ; Jaklová Dytrtová, Jana (advisor) ; Tlapáková, Tereza (referee)
Polycystic ovary syndrome (PCOS) is an endocrine disease caused by hormonal dysbalance. The main criteria for PCOS are hyperandrogenism, oligo-/anovulation and polycystic ovary. Almost 80 % of PCOS woman are also insulin resistance. Insulin resistance is a source of many health problems and diseases. This thesis aims to explore hyperinsulinemia as a consequence of insulin resistance. Hyperinsulinemia ensuses as a compensation for high level of glucose in bloodstream because of insulin resistance. High levels of insulin overstimulate steroidogenesis in follicular cells such as theca cells and granulosa cells. Futhermore, hyperinsulinemia leads to follicular arrest, which can result in infertility. The main aim of this thesis is to summarise information found in scientific publication about hyperinsulinemia in connection with the ovarian cycle and PCOS, including a description of the signaling pathway of insulin in the ovary. Moreover, it aims to compare the ovarian cycle and follicle maturation of healthy woman and woman with PCOS, including pathophysiology such as hyperandrogenism, polycystic ovaries and anovulation.
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Methods of horses laminitis theraphy
Slezáková, Iveta ; Slavík, Petr (advisor) ; Krejčířová, Romana (referee)
This Bachelor labour concerned by treatment of laminis hoofs. The introduction address in particular to history of the disease. Literature review is divided into several chapters. The first is the anatomy of the hoof, which is important for understanding the biological processes that occur during laminitis. The second chapter is focused on this disease and provides explanation and characteristic of laminitis. Listed below are the causes, pathogenesis, action in the hoof, clinical symptoms, more extensive diagnosis and extensive consequences of the disease. The main part of bachelor thesis deals with the treatment and is divided into several sections. Each of them describes the various methods of therapy, the advantages and disadvantages, and at what stage the disease is to be used. It is the elimination of the causes, cryotherapy, rest, analgesics, frog, heels and sole support, foot casts, trimming of hoof, therapeutic shoeing, hirudotherapy and deep flexor tenotomy. The last chapter before the conclusion of a brief comparison of these metods. The conclusion emphasizes some important information for successful therapy.
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