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Measurement and analysis of deposition of fibers from mineral wool in respiratory system
Hájek, Ondřej ; Elcner, Jakub (referee) ; Lízal, František (advisor)
This master thesis deals with inhalation of fine particles and fibres into human lungs. This is a scientific field where computer modelling is used to describe the movement of fibres and their deposition in the lungs. However, the results of these simulations must be verified experimentally. The prediction of fibres behaviour is important from a toxicology point of view where it is important to know deposition hot-spots and places where fibres could possibly cause problems. The review of the state-of-the-art is focused on the deposition of particles in human lungs followed with a chapter on fibre as a type of particle, and occupational exposure limits set by different world associations. The last theoretical chapter describes human lungs and its diseases which can evolve when limits for occupational exposure are not met. The experimental chapter consists of a description of the used experimental setup and results from an experiment together with a comparison of results with other similar experiments.
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Breathing simulator
Stejskal, David ; Jedelský, Jan (referee) ; Lízal, František (advisor)
The purpose of this thesis was to create realistic breathing cycles for breathing simulator and than to verify the functionality of the simulator. The first section of this thesis was conceived as an general introduction to problematics of breathing. This section describes the construction of the lungs, the breathing mechanism and lung volumes. The subject of this study were also important factors that affect human respiration. Processing of acquired data and creation of breathing cycles for breathing simulator is described in the second section of this thesis. Five specific breathing patterns were created. The experimental verification of the breathing simulator functionality is part of the second section.
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Deposition of particles in a model of human lungs
Jakuš, Matúš ; Tuhovčák, Ján (referee) ; Bělka, Miloslav (advisor)
The main purpose of thesis was to do a research of methods suitable for measuring the deposition of particles in human airways. Thesis also contains experiment with porous particles and evaluation of created samples using phase-contrast microscopy. Porous particles seem to be appropriate option for delivering drugs or therapeutic aerosol into the human airways and that made them very interesting in past few years. Theoretical basics of physiology of human airways, aerosols, physical principles of particle deposition and realistic model used during experiment are also explained in this study.
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Deposition of environmental dust particles
Bělka, Miloslav ; Pospíšil, Jiří (referee) ; Jedelský, Jan (advisor)
This work is aimed at deposition of fibers, which are able to penetrate deeper in the human respiratory airways and cause health hazards. Opening chapters are dedicated to classification of aerosols, human lung anatomy basics and methods for measurement of micrometer-sized aerosols. An experiment was carried out to investigate the deposition of fibers. Fibers were delivered into the silicon cast of the human airways and data of deposition fraction and efficiency were acquired. A new method was established to acquire the data. This method works on a principle of image analysis. Results of the new method were compared with a standard method, which follows a methodology NIOSH 7400.
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Measurement and analysis of deposition of fibers from mineral wool in respiratory system
Hájek, Ondřej ; Elcner, Jakub (referee) ; Lízal, František (advisor)
This master thesis deals with inhalation of fine particles and fibres into human lungs. This is a scientific field where computer modelling is used to describe the movement of fibres and their deposition in the lungs. However, the results of these simulations must be verified experimentally. The prediction of fibres behaviour is important from a toxicology point of view where it is important to know deposition hot-spots and places where fibres could possibly cause problems. The review of the state-of-the-art is focused on the deposition of particles in human lungs followed with a chapter on fibre as a type of particle, and occupational exposure limits set by different world associations. The last theoretical chapter describes human lungs and its diseases which can evolve when limits for occupational exposure are not met. The experimental chapter consists of a description of the used experimental setup and results from an experiment together with a comparison of results with other similar experiments.
|
|
|
Breathing simulator
Stejskal, David ; Jedelský, Jan (referee) ; Lízal, František (advisor)
The purpose of this thesis was to create realistic breathing cycles for breathing simulator and than to verify the functionality of the simulator. The first section of this thesis was conceived as an general introduction to problematics of breathing. This section describes the construction of the lungs, the breathing mechanism and lung volumes. The subject of this study were also important factors that affect human respiration. Processing of acquired data and creation of breathing cycles for breathing simulator is described in the second section of this thesis. Five specific breathing patterns were created. The experimental verification of the breathing simulator functionality is part of the second section.
|
|
|
Deposition of environmental dust particles
Bělka, Miloslav ; Pospíšil, Jiří (referee) ; Jedelský, Jan (advisor)
This work is aimed at deposition of fibers, which are able to penetrate deeper in the human respiratory airways and cause health hazards. Opening chapters are dedicated to classification of aerosols, human lung anatomy basics and methods for measurement of micrometer-sized aerosols. An experiment was carried out to investigate the deposition of fibers. Fibers were delivered into the silicon cast of the human airways and data of deposition fraction and efficiency were acquired. A new method was established to acquire the data. This method works on a principle of image analysis. Results of the new method were compared with a standard method, which follows a methodology NIOSH 7400.
|
|
|
Deposition of particles in a model of human lungs
Jakuš, Matúš ; Tuhovčák, Ján (referee) ; Bělka, Miloslav (advisor)
The main purpose of thesis was to do a research of methods suitable for measuring the deposition of particles in human airways. Thesis also contains experiment with porous particles and evaluation of created samples using phase-contrast microscopy. Porous particles seem to be appropriate option for delivering drugs or therapeutic aerosol into the human airways and that made them very interesting in past few years. Theoretical basics of physiology of human airways, aerosols, physical principles of particle deposition and realistic model used during experiment are also explained in this study.
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