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Study of the vasodilatory effect of tamarixetin in an ex vivo porcine coronary vessel model
Gaidosová, Barbora ; Pourová, Jana (advisor) ; Smutný, Tomáš (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Barbora Gaidosová Supervisor: doc. PharmDr. Jana Pourová, Ph.D. Title of diploma thesis: Study of the vasodilatory effect of tamarixetin in an ex vivo porcine coronary vessel model. Flavonoids, as one of the most common herbal substances, are known for their beneficial effects on the human organism and in particular on the cardiovascular system. The aim of this thesis was to screen ten substances contained in hawthorn for vasodilatory effects, select the most active one, and subsequently verify mechanism(s) of its vasodilatory action. The experiments were conducted on an ex vivo vascular model using the pig coronary artery. In screening, the tested substance was always cumulatively added to the precontracted arterial rings at increasing concentrations while monitoring the vasodilatation. Vasoactive inhibitors or agonists of several vasodilatory pathways were used for verification of possible mechanism(s) of action. The results showed that the most active vasodilatory substance was tamarixetine with an EC50 of 47.8 µmol.l-1 . The detail mode of action has not been discovered however tamarixetine has been shown to influence the voltage dependent calcium channels of L-type on the vascular smooth...
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Využití některých méňě pěstovaných ovocných druhů pro zpracování
Střihavková, Dana
The bachelor essay on "The use of less cultivated fruit species for processing" topic focuses on the processing three non?-traditional fruit species such as hawthorn, medlar and quince. A total of 11 products, produced from these fruit species, were evaluated by anonymous sensory evaluation by 15 respondents. The gustation was based on criteria such as taste, smell, appearance, consistency and overall impression. The best products were the hawthorn products, then the quince, and at least the medlar products. Less usual fruit species can undoubtedly be an interesting diversification of our diet, and due to the significant part of nutritionally valuable substances, they can enrich the assortment of products from commonly grown fruit species.
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Pomologické hodnocení vybraných méně pěstovaných jádrovin
Sikorowská, Monika
This diploma thesis is about some less grown pome fruit species like Rowan, Service Tree, Hawthorn, Medlar, Crataegomespilus Simon-Louis and Sorbopyrus Scheele. Thesis is focused on the observation of individual phenophases for this species and recording of the numbers of flowers and fruits on them. Work is focused mainly on pomological description of mentioned species and variety. Contain statistically processed data about fruit size. In experimental part of the thesis are values for vitamin C content, carotenoids and minerals (K, Na, Ca, Mg) content, which were also valuated statistically. The result outcome of this thesis is chosen species and cultivar for the climate conditions of Czech Republic.
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Možnosti pěstování některých méně pěstovaných ovocných druhů v ČR
Rózsová, Ivana
This bachelor thesis is dedicated to lesser cultivated fruit species (Crataegus laevigata (Poir. in Lam.) DC, Crataegus pinnatifida Bunge, Cydonia oblonga Mill., Mespilus germanica L. a Sorbus domestica L.), their specification from a taxonomic and morphological point of view, and deals with options of growing these species on area of Czech Republic. It also describes some possibilities of processing the fruit (processing of medlar was only described theoretically) and compares the success of each product in sensory evaluation. It was proven that these species are suitable for industrial and home utilization. They should serve as an enlargement of a market assortment.
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