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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Complete genome sequence analysis of TBE virus, strain Hypr, in different passages in host \kur{in vivo}.
 ŠIMONOVÁ, Zuzana
I have compared genomic sequences of three variants of tick-borne encephalitis virus, strain Hypr. The variants used were Hypr5 {--} virus passaged five times in suckling mice brains, Hypr50/V {--} a variant highly passaged in vivo in Vienna, and Hypr50/CB {--} a variant highly passaged in vivo in České Budějovice. Both high-passage variants were passaged in suckling mouse brains as well. I was interested in changes in nucleotide sequence of genomes of high-passage variants Hypr50/V and Hypr50/CB compared with Hypr5 and also consequential changes in amino-acid sequences of viral proteins. I have found several identical changes in amino-acid sequences of E protein, NS3 and NS5 proteins in both high-passage variants and also a number of substitutions unique to one of the variants in proteins E, NS1, NS2A, NS2B, and NS3. A nucleotide substitution was found also in 5{\crq}UTR of the viral genome.
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