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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Analýza produktů fotochemické degradace vybraných léčiv (dexametazonu, prednisolonu) pomocí LC/MS
 PONCAROVÁ, Martina
The diploma thesis investigates photoinitiated degradation of two representatns of the inflamatory drugs, dexamethasone and prednisolone, when irradiated by UV light corresponding with the high-energy solar radiation reaching the Earth surface. The study based on HPLC/MS technique presents the possible pathways of photodegradation of the drugs and proposes structures of photochemically formed products.
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Fotoiniciovaná degradace vybraných léčiv (dexametazonu, prednisolonu, fluoxetinu) a testování toxicity léčiv a produktů jejich fotodegradace na vodní organismy (\kur{Daphnia magna})
 DOKOUPILOVÁ, Eliška
This diploma thesis investigates kinetics of photoinitiated degradation of selected drugs (dexamethasone, prednisolone, fluoxetine) under conditions relevant to surface waters and provides results of toxicity tests of original compounds and their photodegradation products mixtures for a representant of aquatic organisms, cladoceran Daphnia magna. The theoretical part describes the basic characteristics, mechanism of action and therapeutic usage of selected drugs. Toxicological studies related to adverse effects of these substances on aquatic organisms are also briefly outlined. The experimental part presents first the results of photochemical degradation kinetics of the studied compounds and second the findings of chronic toxicity tests of the selected drugs and their photoproducts mixtures on Daphnia magna, namely on the number of juveniles, on the number of clutches and on the body size.
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