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Alluminium complexes for biomedical applications
Beranová, Tereza ; Kubíček, Vojtěch (advisor) ; Havlíček, David (referee)
The aim of this work was to prepare ligands of macrocycle TACN with aminophosphinate pendant arms. Two ligands were prepared and fully characterized. A complex of aluminium ion was synthesized with one of the ligand. The complex was used for studying a fluoride coordination by a fluoride ion selective electrode. Key words: macrocyclic complex, positron emission tomography, phosphinic acid
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Aminophosphinic acids
Kruliš, Tomáš ; Kubíček, Vojtěch (advisor) ; Gyepes, Róbert (referee)
Two phosphinic acids were prepared: 1-hydroxy-ethan-1,1-bis[N,N- bis(karboxymethyl)aminomethyl]phosphinic acid; H6L1 and methylenebis[N,N- bis(karboxymethyl)aminomethyl]phosphinic acid; H6L2 . Acid-base and complexation properties were studied by potenciometric titrations. Complexes of both ligands with Cu2+ ions were studied in detail using UV/VIS spectrometry. Keywords: Organophosphorus synthesis, bisphosphinic acids, coordination properties
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TACN derivatives bearing aminophosphinate pendant arms
Beranová, Tereza ; Kubíček, Vojtěch (advisor) ; Němec, Ivan (referee)
The aim of this work was studying of the coordination properties of TACN macrocyclic derivatives with aminophosphinate pendant arms. Two ligands were prepared, one with two pendant arms NODPam and one with three pendant arms NOTPam. Because of degradation of ligand NODPam during its synthesis, only the ligand NOTPam was studied further. Acid-base properties of ligand and termodynamic stability of aluminium and gallium complexes were studied. Formation and disociation studies were performed with the complexes. Coordination of fluoride ions to aluminium complex was studied using ion selective fluoride electrode. Finally coordination of complex AlFx with ligand NOTPam was studied using 19F and 27Al NMR spectroscopy. Selected experiments were made also with ligand NOTA. Key words: macrocyclic complexes, positron emission tomography, phosphinic acids
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Macrocyclic ligands for selective complexation of large cations
Šefčík, Martin ; Kotek, Jan (advisor) ; Vojtíšek, Pavel (referee)
4 Abstract Nowadays, macrocyclic complexes of actinides receive an increasing attention for their potential applications in radiotherapy. It requires significant demands on their thermodynamic and kinetic stability which are particularly influenced by an appropriate choice of a ligand. This Thesis focuses on a synthesis and characterization of two ligands that are potentially applicable for complexation of lanthanum as a model of radioactive actinium. Both ligands are based on a fifteen-membered cycle containing pyridine group, 15-pyN3O2. The first ligand, H4L1, contains two phosphonate pendant arms. The second ligand, H2L2, contains two phosphinate pendant arms. Both compounds were prepared and characterized. Keywords Macrocyclic ligands, large cations, phosphonic acids, phosphinic acids, dissociation constants
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Contrast agents for 19F MRI
Koucký, Filip ; Kotek, Jan (advisor) ; Vojtíšek, Pavel (referee)
For 19 F MRI the fluorinated contrast agents should be endowed by short relaxation times. Paramagnetic metal ions make relaxation times shorter and this effect depends on the distance between the metal ion and 19 F nuclei. The aim of this thesis is the synthesis of suitable ligand containing fluorine atoms, and a preparation of its Ni2+ and Cu2+ complexes. Macrocyclic 1,4,8,11- tetraazacyclotetradecane (cyclam) was selected as a starting material as it has optimal ring-size for complexation of the selected ions. The parent macrocycle was substituted by fluorine-containing coordinating pendant arms. Key words: Cyclam; Contrast agents; Phosphonic acids, 19 F MRI, Paramagnetic relaxation, d-metals
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Aminophosphinic acids
Kruliš, Tomáš ; Kubíček, Vojtěch (advisor) ; Gyepes, Róbert (referee)
Two phosphinic acids were prepared: 1-hydroxy-ethan-1,1-bis[N,N- bis(karboxymethyl)aminomethyl]phosphinic acid; H6L1 and methylenebis[N,N- bis(karboxymethyl)aminomethyl]phosphinic acid; H6L2 . Acid-base and complexation properties were studied by potenciometric titrations. Complexes of both ligands with Cu2+ ions were studied in detail using UV/VIS spectrometry. Keywords: Organophosphorus synthesis, bisphosphinic acids, coordination properties
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TACN derivatives bearing aminophosphinate pendant arms
Beranová, Tereza ; Kubíček, Vojtěch (advisor) ; Němec, Ivan (referee)
The aim of this work was studying of the coordination properties of TACN macrocyclic derivatives with aminophosphinate pendant arms. Two ligands were prepared, one with two pendant arms NODPam and one with three pendant arms NOTPam. Because of degradation of ligand NODPam during its synthesis, only the ligand NOTPam was studied further. Acid-base properties of ligand and termodynamic stability of aluminium and gallium complexes were studied. Formation and disociation studies were performed with the complexes. Coordination of fluoride ions to aluminium complex was studied using ion selective fluoride electrode. Finally coordination of complex AlFx with ligand NOTPam was studied using 19F and 27Al NMR spectroscopy. Selected experiments were made also with ligand NOTA. Key words: macrocyclic complexes, positron emission tomography, phosphinic acids
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Alluminium complexes for biomedical applications
Beranová, Tereza ; Kubíček, Vojtěch (advisor) ; Havlíček, David (referee)
The aim of this work was to prepare ligands of macrocycle TACN with aminophosphinate pendant arms. Two ligands were prepared and fully characterized. A complex of aluminium ion was synthesized with one of the ligand. The complex was used for studying a fluoride coordination by a fluoride ion selective electrode. Key words: macrocyclic complex, positron emission tomography, phosphinic acid
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Synthesis of phosphinic acids
Kruliš, Tomáš ; Kubíček, Vojtěch (advisor) ; Schulz, Jiří (referee)
Two types of phosphinic acids were prepared: N,N-bis(carboxymethyl)aminomethyl phosphinic acid and carboxyethylphosphinic acid. Afterwards they were used to synthesize bisphosphinic acids: 1-hydroxy-ethan-1,1-bis[N,N-bis(carboxymethyl)aminomethyl phosphinic] acid and 1-hydroxy-ethan-1,1-bis(carboxyethyl)phosphinic acid. All compounds were characterized by NMR and mass spectroscopy. N,N-bis(carboxymethyl)aminomethylphosphinic acid was synthesized by Mannich type reaction. Carboxyethylphosphinic acid was prepared by alkylation of bis(trimethylsilyloxy)phosphine. Both bisphosphinic acids were prepared by reaction of silylesters of phosphinic acids with acetylchloride. All compounds were prepared in moderate or good yields. Keywords: Organophosphorus synthesis, phosphinic acids, bisphosphinic acids
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