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Drugs Loading in Thermosensitive Micellar Gels
Smolková, Miroslava ; Pavliňáková, Veronika (referee) ; Chamradová, Ivana (advisor)
Presented diploma thesis deals with drug encapsulation of Sulfathiazole (STA) in thermosensitive hydrogel composed of amphiphilic fibrous molecules of copolymer poly(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA). In the experimental part, the structure of the micelles which is dependent on the concentration of the default copolymer, was thoroughly described. The method of dynamic light scattering (DLS) was used to dimensionally characterize the micellar size in aqueous solution. At the same time, the Cryo-Transmission Electron Microscopy (Cryo-TEM) imaging technique confirmed the transition from spherical micelles to fibrous branched structures with a number of topological interactions. The change in viscoelastic properties of micellar hydrogel after addition of STA was studied by rheological analysis. The studied triblock copolymer appears to be a suitable tissue engineering material as a carrier in applications for targeted drug delivery and tissue regeneration.
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Novel materials for NLO applications based on guanidine derivatives - crystal engineering and detailed characterisation
Kohúteková, Soňa ; Němec, Ivan (advisor) ; Kalbáč, Martin (referee) ; Vlčková, Blanka (referee)
Title: Novel materials for NLO applications based on guanidine derivatives - crystal engineering and detailed characterisation Author: Mgr. Soňa Kohúteková Department: Department of Inorganic Chemistry Supervisor: prof. RNDr. Ivan Němec, Ph.D. Abstract: This doctoral thesis is focused on the preparation and characterisation of new compounds for potential application in nonlinear optics (NLO). Four molecules containing guanidine fragment were chosen as the carriers of NLO properties - aminoguanidine, diaminoguanidine, N-guanidine-formamide and 1H-pyrazole-carboxamidine, according to the promising preliminary results of hyperpolarizability values obtained by quantum-chemical calculations. Experimental work was divided into two main directions of preparation of new crystalline materials - preparation of perovskite metal-organic frameworks (MOFs) and molecular crystals. In the first group of studied materials, target molecules were expected to occupy cavities of frameworks built by formate anions coordinated to metal cations. In the second group, in the molecular crystals, carriers of NLO properties were co-crystallised with selected inorganic anions to prevent the formation of centrosymmetric dimers and to influence the desired crystal packing. Prepared materials were characterised mainly by the means of...
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Algebraic approaches to elementary excitations in media with broken spatial or time-reversal symmetry
Erb, Kay Condie ; Hlinka, Jiří (advisor) ; Mokrý, Pavel (referee) ; Schranz, Wilfried (referee)
Title: Algebraic Approaches to Elementary Excitations in Media with Broken Spatial or Time-reversal Symmetry Author: Kay Condie Erb Institute: Institute of Physics of the Czech Academy of Sciences Supervisor: Ing. Jiří Hlinka, Ph.D., Institute of Physics of the Czech Academy of Sciences Abstract: Structural phase transitions with macroscopic symmetry breaking can be divided into 212 non-magnetic species according to the mutual spatial orien- tation of the point groups of both phases. Classification into the given species implies a set of universal transition properties such as the number of macroscopic domain states of the low-symmetry phase and their distinguishability by order parameter. In this work, the distinguishability of macroscopic domain states by all order pa- rameters which transform as vectors or vectorlike quantities (called bidirectors) was studied. For solving this task, a computer algorithm was designed which enabled an explicit listing of all vector and vectorlike order parameters, not only for the 212 non-magnetic species, but even for all 1602 magnetic species which includes transitions between crystallographic gray and bicolor point groups. In addition, irreducible representations of the 122 magnetic crystallographic point groups which transform as vectors or vectorlike quantities are...
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Phase transformation in magnesium MgZnAl-based alloys
Kodetová, Veronika ; Vlach, Martin (advisor) ; Mathis, Kristián (referee)
In the present work, there was analyzed thermal evolution of the phase transformation in the MgZnAl and MgZnAlCa alloys with different concentration of the Zn and Ca. The grains were occupied by the phase with quasicrystaline icosaedral structure in the as-cast alloys and after isochronal annealing up to 240 řC. The thermal measurements revealed two exothermic effects in the MgZnAl alloy and three exothermic effects in the MgZnAlCa alloy during linear heat treatment in the temperature range of 100 - 250 řC. In agreement to the thermal response, two and three stages of electrical resistivity decrease were observed in the same temperature range. The lower thermal changes, absolute resistivity changes and microhardness were observed in the alloy with Ca-addition and lower concentration of Zn.
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Nucleation in complex systems
Kulveit, Jan ; Demo, Pavel (advisor) ; Slanina, František (referee) ; Vlček, Jaroslav (referee)
Title: Nucleation in complex systems Author: Jan Kulveit Institute: Institute of Physics of the Czech Academy of Sciences Supervisor: prof. Pavel Demo, Institute of Physics of the Czech Academy ofSciences, Department of Optical Materials Abstract: We studied nucleation in progressively more abstract contexts and systems, starting from classical nucleation theory and ending with nucleation in complex networks. The cases studied include impurity nucleation in a solid matrix on several alkali halide crystals, where we determined formation energies for clusters, treated as defects, starting from single impurity-vacancy dipole and small aggregates to possible configurations of larger clusters. In the next part, we turn to the study of heterogeneous nucleation. While in the usual treatment of heterogeneous nucleation the surface energy is assumed to be homogenous, we ask the question what happens if we consider the surface energy to be heteroge- neous.Utilizing umbrella sampling computer simulations we find the nucleation barrier can be significantly lowered in the presence of surface heterogeneity, even if the average surface energy is kept constant. In the last part we study influence of clustering coefficient on phase transitions in scale-free networks, using forward flux sampling (FFS). Keywords: nucleation,...
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Phase transformation in bio-compatible Mg-based alloys
Hornát, Bohumil ; Vlach, Martin (advisor) ; Mathis, Kristián (referee)
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Phase transformation in magnesium MgZnAl-based alloys
Kodetová, Veronika ; Vlach, Martin (advisor)
In the present work, there was analyzed thermal evolution of the phase transformation in the MgZnAl and MgZnAlCa alloys with different concentration of the Zn and Ca. The grains were occupied by the phase with quasicrystaline icosaedral structure in the as-cast alloys and after isochronal annealing up to 240 řC. The thermal measurements revealed two exothermic effects in the MgZnAl alloy and three exothermic effects in the MgZnAlCa alloy during linear heat treatment in the temperature range of 100 - 250 řC. In agreement to the thermal response, two and three stages of electrical resistivity decrease were observed in the same temperature range. The lower thermal changes, absolute resistivity changes and microhardness were observed in the alloy with Ca-addition and lower concentration of Zn.
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Latent heat effect on slab deformation in the Earth mantle
Pilař, Štěpán ; Čížková, Hana (advisor) ; Běhounková, Marie (referee)
Lithospheric plates move relative to each other with velocities of several cm/year. In subduction zone, one plate slides (subducts) under the other. Slabs are being deformed while subducting to the Earth's mantle. The subduction is influenced by phase tran- sitions of the mantle material at the depths of 410 km and 660 km. Here, we used a two-dimensional numerical model of subduction to evaluate the influence of latent heat released or absorbed during these phase transitions on the subduction process. We ex- amined the influence of latent heat alongside the influence of other parameters - age of the slab (50 - 150 million years), yield stress inside the slab (2 · 108 − 5 · 108 Pa) and viscosity of the crust (1020 −1021 Pa s). Latent heat released during an exothermic phase transition at the depth of 410 km heats up the slab by 50 - 90 K, reduces the density anomaly with respect to the surrounding mantle and slows down the slab. At the same time, the viscosity of the slab is lowered and the slab deforms more easily in the transi- tion zone due to the endothermic phase transition at the depth of 660 km and a viscosity resistance of a stiffer lower mantle. The stress inside a slab is therefore lowered, which may influence deep earthquakes. When it comes to the other parameters, age of the slab changes the...
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Algebraic approaches to elementary excitations in media with broken spatial or time-reversal symmetry
Erb, Kay Condie ; Hlinka, Jiří (advisor) ; Mokrý, Pavel (referee) ; Schranz, Wilfried (referee)
Title: Algebraic Approaches to Elementary Excitations in Media with Broken Spatial or Time-reversal Symmetry Author: Kay Condie Erb Institute: Institute of Physics of the Czech Academy of Sciences Supervisor: Ing. Jiří Hlinka, Ph.D., Institute of Physics of the Czech Academy of Sciences Abstract: Structural phase transitions with macroscopic symmetry breaking can be divided into 212 non-magnetic species according to the mutual spatial orien- tation of the point groups of both phases. Classification into the given species implies a set of universal transition properties such as the number of macroscopic domain states of the low-symmetry phase and their distinguishability by order parameter. In this work, the distinguishability of macroscopic domain states by all order pa- rameters which transform as vectors or vectorlike quantities (called bidirectors) was studied. For solving this task, a computer algorithm was designed which enabled an explicit listing of all vector and vectorlike order parameters, not only for the 212 non-magnetic species, but even for all 1602 magnetic species which includes transitions between crystallographic gray and bicolor point groups. In addition, irreducible representations of the 122 magnetic crystallographic point groups which transform as vectors or vectorlike quantities are...
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Nucleation in complex systems
Kulveit, Jan ; Demo, Pavel (advisor) ; Slanina, František (referee) ; Vlček, Jaroslav (referee)
Title: Nucleation in complex systems Author: Jan Kulveit Institute: Institute of Physics of the Czech Academy of Sciences Supervisor: prof. Pavel Demo, Institute of Physics of the Czech Academy ofSciences, Department of Optical Materials Abstract: We studied nucleation in progressively more abstract contexts and systems, starting from classical nucleation theory and ending with nucleation in complex networks. The cases studied include impurity nucleation in a solid matrix on several alkali halide crystals, where we determined formation energies for clusters, treated as defects, starting from single impurity-vacancy dipole and small aggregates to possible configurations of larger clusters. In the next part, we turn to the study of heterogeneous nucleation. While in the usual treatment of heterogeneous nucleation the surface energy is assumed to be homogenous, we ask the question what happens if we consider the surface energy to be heteroge- neous.Utilizing umbrella sampling computer simulations we find the nucleation barrier can be significantly lowered in the presence of surface heterogeneity, even if the average surface energy is kept constant. In the last part we study influence of clustering coefficient on phase transitions in scale-free networks, using forward flux sampling (FFS). Keywords: nucleation,...
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