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Womenś awareness of endometriosis in the Czech Republic
Fridrichová, Tereza ; Fanta, Michael (advisor) ; Černý, Andrej (referee)
The theme of my bachelor thesis is called "Awareness of women about endometriosis in the Czech Republic". The thesis consists of two parts - theoretical and practical. In the theoretical part, I deal with the anatomy and physiology of female genitals. The next chapter focuses directly on endometriosis. Contains subchapters related to with the characteristics, origin, clinical symptoms, diagnosis, treatment, etc. Last but not least, I focus on the role of the midwife in the care of a woman with endometriosis. In the practical part, I examined women's awareness of endometriosis. To collect the data, I used an anonymous quantitative questionnaire, which I shared using social networks. The questionnaire could be filled in by a woman of all ages living in the Czech Republic. 106 respondents took part in the research, who filled in a questionnaire in the period from 10 February 2020 to 9 March 2020. Before starting the practical part, I set out hypotheses that I was able to confirm or refute thanks to the obtained questionnaires. My main goal was to find out how many women know what is endometriosis. Based on this goal, I set a hypothesis, which was confirmed and that more than half of the respondents know the disease. Because these are the days one of the most common gynecological diseases, I assumed...
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Study of mechanism of action of anticancer drug tamoxifen and its toxic side effects
Kylarová, Salome ; Stiborová, Marie (advisor) ; Moserová, Michaela (referee)
Anti-estrogen therapy is used for treatment of hormone (estrogen) receptor positive breast cancer. The rise of this type of cancer is associated with a prolonged exposure to these hormones throughout life. Tamoxifen is one of the most used hormonal drugs, which blocks the effects of these hormones in breast cancer tissue by competitive binding to hormonal receptors. The affinity of tamoxifen to these receptors is not sufficient, therefore it has to be activated to metabolites having greater affinity, namely 4-hydroxytamoxifen and endoxifen. The formation of these intermediates is catalysed by cytochromes P450. In the second phase of its biotransformation hydroxylated metabolites of tamoxifen are primarily sulphated by sulphotransferases and eliminated from the body. In addition to these active intermediates, which inhibit the growth of breast tumor tissue, there are metabolites causing negative effects in the others. The most important metabolite is α-hydroxytamoxifen, which forms covalent DNA adducts in liver tissue of rats and endometrium of females. Tamoxifen therapy is associated with numerous side effects, but the greatest attention is focused to formation of endometrial cancer and induction of tumor's resistance to this therapy. Effects of tamoxifen therapy are dependent on the activity of...
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Womenś awareness of endometriosis in the Czech Republic
Fridrichová, Tereza ; Fanta, Michael (advisor) ; Černý, Andrej (referee)
The theme of my bachelor thesis is called "Awareness of women about endometriosis in the Czech Republic". The thesis consists of two parts - theoretical and practical. In the theoretical part, I deal with the anatomy and physiology of female genitals. The next chapter focuses directly on endometriosis. Contains subchapters related to with the characteristics, origin, clinical symptoms, diagnosis, treatment, etc. Last but not least, I focus on the role of the midwife in the care of a woman with endometriosis. In the practical part, I examined women's awareness of endometriosis. To collect the data, I used an anonymous quantitative questionnaire, which I shared using social networks. The questionnaire could be filled in by a woman of all ages living in the Czech Republic. 106 respondents took part in the research, who filled in a questionnaire in the period from 10 February 2020 to 9 March 2020. Before starting the practical part, I set out hypotheses that I was able to confirm or refute thanks to the obtained questionnaires. My main goal was to find out how many women know what is endometriosis. Based on this goal, I set a hypothesis, which was confirmed and that more than half of the respondents know the disease. Because these are the days one of the most common gynecological diseases, I assumed...
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|
|
Study of mechanism of action of anticancer drug tamoxifen and its toxic side effects
Kylarová, Salome ; Stiborová, Marie (advisor) ; Moserová, Michaela (referee)
Anti-estrogen therapy is used for treatment of hormone (estrogen) receptor positive breast cancer. The rise of this type of cancer is associated with a prolonged exposure to these hormones throughout life. Tamoxifen is one of the most used hormonal drugs, which blocks the effects of these hormones in breast cancer tissue by competitive binding to hormonal receptors. The affinity of tamoxifen to these receptors is not sufficient, therefore it has to be activated to metabolites having greater affinity, namely 4-hydroxytamoxifen and endoxifen. The formation of these intermediates is catalysed by cytochromes P450. In the second phase of its biotransformation hydroxylated metabolites of tamoxifen are primarily sulphated by sulphotransferases and eliminated from the body. In addition to these active intermediates, which inhibit the growth of breast tumor tissue, there are metabolites causing negative effects in the others. The most important metabolite is α-hydroxytamoxifen, which forms covalent DNA adducts in liver tissue of rats and endometrium of females. Tamoxifen therapy is associated with numerous side effects, but the greatest attention is focused to formation of endometrial cancer and induction of tumor's resistance to this therapy. Effects of tamoxifen therapy are dependent on the activity of...
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