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Use of biomarkers for the diagnosis and prevention of preeclampsia and eclampsia
Beránková, Hana ; Kovařík, Miroslav (advisor) ; Patková, Anna (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Author: Hana Beránková Supervisor: PharmDr. Miroslav Kovařík, PhD. Title of the bachelor thesis: Use of biomarkers for the diagnosis and prevention of preeclampsia and eclampsia Aim of the thesis: The aim of this thesis was to gain an overview of preeclampsia, to summarize the findings of laboratory examinations for the diagnosis of this disease and to focus on the biochemical markers necessary to recognize the disease. Main findings: Preeclampsia is a hypertensive disease, which today is a major complication of pregnancy. Because of the undetermined etiology, neither the prediction nor the diagnosis of this disease is simple. The levels of some biomarkers, measurable in both blood and urine, make it easier to recognize the approaching disease before the first clinical manifestations. However, there is no factor that would reliably determine whether it is preeclampsia. Therefore, combinations of different markers are currently used. Conclusion: The number of markers shown here proves that it is not easy to define the most reliable ones. Today, physicians choose methods to investigate angiogenic factors and the ratio of soluble fms like tyrosine kinase to placental growth factor...
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Seizures in the prehospital emergency care
JAŠKOVÁ, Lucie
This bachelor's thesis on the subject: "Seizures in the prehospital emergency care" is divided into two parts. A theoretical part, and a research part. The theoretical part is initially devoted to the general description of the spasmodic states and their development. Consequently, the spasmodic states are divided according to the characteristics of the spasm, the extent of the seizure and the cause of the spasm. An overview of selected conditions that cause spasmodic activity is featured in the subchapters. The core of the work is dedicated to epilepsy, epileptic status, febrile convulsions and eclampsia. For the research part, objective 1 was: to map the level of the theoretical knowledge of paramedics in connection with the provision of pre-hospital emergency care in case of spasmodic states. Two research questions were identified on the basis of this objective. The research question number 1 is: How do paramedics, from differential diagnosis point of view, care for a patient, who is in spasmodic state? The research question number 2 is: How do paramedics proceed, from therapy point of view, in treatment of a patient, who suffers from spasmodic state? A qualitative research method, in the form of semi-structured interviews, was used to question 6 paramedics who work at the Medical Emergency Service in Tábor and České Budějovice. The participants responded 12 questions and with their consent, were recorded on a Dictaphone. The data obtained was divided into 10 categories. The research has revealed a lack of knowledge of paramedics regarding the problem of spasmodic states in pre-hospital emergency care. As the adequate knowledge and skills of paramedics are necessary, I consider their periodic testing useful.
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