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Interaction between amphiphilic fluorescent probes and hyaluronan
 Střondalová, Hana ; Vala, Martin (referee) ; Mravec, Filip (advisor)
This bachelor thesis dealt with studying the interaction of amphiphilic fluorescent probes with hyaluronan because these probes could significantly help in clarifying the links between hyaluronan and surfactants. This complex could be a great benefit in targeting drug distribution. This thesis was focused on the interaction between hyaluronan and amphiphilic fluorescent probes – specifically with dodecylacridine orange. First explored was the interaction with hyaluronan, and then with the hyaluronan – surfactant system. Cetyltrimethylamonium bromide was selected as surfactant. Samples were examined using fluorescence spectroscopy. Emission and absorption spectrum of dodecyl acridine orange was measured. This experiment was based on the hypothesis that dodecylacridine orange forms dimers as acridine orange and nonylacridine orange. It was found that in a system of hyaluronan-probe, dodecyl acridine orange was pushed out of the complex by cetyltrimethylamonium bromide, which was bounded instead. Surfactant interacts with hyaluronan binding positions - with carboxyl groups.
Detailed record
Interaction between amphiphilic fluorescent probes and hyaluronan
 Střondalová, Hana ; Vala, Martin (referee) ; Mravec, Filip (advisor)
This bachelor thesis dealt with studying the interaction of amphiphilic fluorescent probes with hyaluronan because these probes could significantly help in clarifying the links between hyaluronan and surfactants. This complex could be a great benefit in targeting drug distribution. This thesis was focused on the interaction between hyaluronan and amphiphilic fluorescent probes – specifically with dodecylacridine orange. First explored was the interaction with hyaluronan, and then with the hyaluronan – surfactant system. Cetyltrimethylamonium bromide was selected as surfactant. Samples were examined using fluorescence spectroscopy. Emission and absorption spectrum of dodecyl acridine orange was measured. This experiment was based on the hypothesis that dodecylacridine orange forms dimers as acridine orange and nonylacridine orange. It was found that in a system of hyaluronan-probe, dodecyl acridine orange was pushed out of the complex by cetyltrimethylamonium bromide, which was bounded instead. Surfactant interacts with hyaluronan binding positions - with carboxyl groups.
Detailed record

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