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Positive and negative aspects of ketosis on human health
Kulhavá, Barbora ; Martínková, Markéta (advisor) ; Alán, Lukáš (referee)
The bachelor thesis deals with the issue of ketosis and ketogenic diets. It describes the process of formation of ketone bodies and its regulation, it also focuses on the process of utilization of ketone bodies in peripheral tissues. The goal of this thesis was to summarize the positive benefits of ketosis in the treatment of some serious diseases, its effectiveness in reducing body weight and its positive benefits in the adaptation of the human body to starvation. The work also focuses on the possible negative influence of ketogenic diets in the development of chronic kidney disease. After processing the literature sources on the problem of negative and positive aspects of ketosis on the human body, it became clear that under professional guidance, the ketogenic diet and ketosis that is associated with it have an overwhelmingly positive effect on the human health. KEY WORDS: Ketosis, ketogenic diet, ketone bodies, cancer treatment, childhood epilepsy, ketoacidosis
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Adverse effects of epilepsy medication in children
Arnošová, Karolína ; Herink, Josef (advisor) ; Vopršalová, Marie (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biological and medicinal sciences Candidate Karolína Arnošová Consultant doc.MUDr. Josef Herink DrSc. Title of thesis Adverse effects of epilepsy medication in children The aim of this thesis was to determine the most commonly used antiepileptics in children, its adverse effects and to compare these results with the adult epileptology. In the theoretical part there are etiopathogenesis, pathophysiology, clinical manifestation, types of the seizures and epileptic syndromes described. The specifics of epilepsy treatment in children, not only pharmacotherapy, but also non-pharmacological treatment options, were documented as well. In the study there was exact half of patients treated with monotherapy and the other half with combined therapy which is not in line with the original hypothesis that assumed a predominance of monotherapy. The most commonly used antiepileptics in children were valproate (62,5 %), lamotrigine (25 %), topiramate and levetiracetame (both in 18,75 %). The hypothesis assuming a higher incidence of adverse effects in combination therapy has been confirmed. The most common adverse effects in children were the effects on total daily activity, occuring in 83,33 %, even with the mildest score on average....
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