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Cytototoxic effects of antiseptics in devices for chronic wound healing
Kejzlarová, Leona ; Pavlík, Vojtěch (advisor) ; Hrdý, Jiří (referee)
Chronic wounds are often colonized by pathogens bacteria. The occurrence of infection on the surface results in an injured and delayed healing process. Therefore, the use of antimicrobial agents that eliminate microbiological stress and prevent infection is required for the treatment of chronic wounds. Microbial agents include antibiotics, but pathogens are able to develop resistance to them. Antiseptic agents are therefore used, which act non-selectively. Antiseptics may be cytotoxic to human tissue cells and cause a delay in wound healing. A certain balance needs to be struck between antimicrobial activity and cytotoxicity. The most commonly used active substances with microbicidal properties in antiseptic preparations are: silver, iodine, chlorine, octenidine, polyhexanide, and chlorhexidine. This work describes the mechanisms of action of these agents and compares the clinical and laboratory knowledge of their effectiveness in chronic wound healing and cytotoxicity against cells involved in this process. Keywords: Chronic wounds, antiseptic, cytotoxicity, octenidine, chlorhexidine, polyhexamethylen, PHMB, iodine, silver, chlor
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