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National Repository of Grey Literature

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Autophagy as a biochemical phenomenon of neurodegeneration Čechová, Kateřina ; Vrajová, Monika (advisor) ; Žurmanová, Jitka (referee) Autophagy is a nonspecific catabolic process which targets damaged organelles, proteins and intracellular pathogens. Autophagy becomes less efficient with normal and also with accelerated aging. Electron microscopy studies on brain of patients with Alzheimer's disease provide evidence that autophagy is involved in the neurodegenerative process. Stimulation of autophagy has a neuroprotective effect and help to degrade changed or aggregated proteins. Detailed record

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