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	Detection of poorly differentiated cardiac arrhythmias Kantor, Marek ; Ronzhina, Marina (referee) ; Novotná, Petra (advisor) This thesis focusses on the detection methods of atrial fibrilation, atrial flutter and sinus rhythm from ECG. Thesis also concentrate on the description of this arrhythmias and the learning algorithms used. In this thesis are implemented several classification approaches. For extraction of features is used convolution neural network and classification artifitial neural network. Selected 1D CNN method achived classification accuracy global F1 - score is 91 %. Moreover, the proposed CNN optimized with GA appears to be fast shallow network with better accuracy than the deep network. Created model are used for classification other type of arrhythmias too. Detailed record
	Detection of poorly differentiated cardiac arrhythmias Kantor, Marek ; Ronzhina, Marina (referee) ; Novotná, Petra (advisor) This thesis focusses on the detection methods of atrial fibrilation, atrial flutter and sinus rhythm from ECG. Thesis also concentrate on the description of this arrhythmias and the learning algorithms used. In this thesis are implemented several classification approaches. For extraction of features is used convolution neural network and classification artifitial neural network. Selected 1D CNN method achived classification accuracy global F1 - score is 91 %. Moreover, the proposed CNN optimized with GA appears to be fast shallow network with better accuracy than the deep network. Created model are used for classification other type of arrhythmias too. Detailed record
	Evaluation of cost effectiveness of NOAC (New Oral AntiCoagulants) in the indication of atrial fibrillation Vothová, Petra ; Lešetický, Ondřej (advisor) ; Pažitný, Peter (referee) In my thesis, in the theoretical part I deal with atrial fibrillation. I also deal with management of atrial fibrillation treatment. In the paper I explain the basic principles of pharmaco-economic evaluation in the Czech Republic, on the basis of which laws these pharmacological interventions are evaluated and who are in the Czech Republic. In the work I present cost breakdown and what are the most commonly used pharmaco-economic analyzes. In the practical part I will apply the theoretical knowledge. I have developed cost utility analysis based on available clinical evidence - randomized clinical trials ARISTOTLE (Granger, 2011), RE-LY (Connolly, 2009), ROCKET AF (Patel, 2011). I made an indirect comparison of the total benefits of NOACs. In the baseline scenario, I have calculated QALY to evaluate the benefits of effectiveness, safety and reduction of mortality. I have also dealt with a bleeding-related scenario. The ICER's greatest contribution to the public healthcare system has shown the active substance apixaban in both scenarios. I added the results and confirmed the clinical results of a recent, robust, retrospective study by Mayo Clinic (Yao, 2016). Detailed record

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