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INFECTION AS A RISK FACTOR DURING PREGNANCY
HRUBEŠOVÁ, Martina
The thesis Infection as a risk factor during pregnancy is divided into two parts {--} theoretical and practical {--} and has a character of a research study. The theoretical part deals with aspects of infections during pregnancy. The main attention is paid to the questions of pregnant women colonized with group B Streptococci (GBS, Streptococcus agalactiae) which may cause a large scale of infectious diseases in newborns, including the life threatening sepsis. This part of the thesis is divided into seven chapters. They provide brief information on the etiological agent, risk factors, clinical picture of the disease, current possibilities of the disease diagnostics. The present day system of the optimal procedure of screening to identify women colonized with GBS and the procedure of the intrapartal antibiotic prophylaxis are also mentioned in the theoretical part. The objective of the practical part is to find the percentage of newborn infants delivered by mothers colonized with GBS who are also colonized with GBS despite their mothers having been treated by the intrapart antibiotic prophylaxis. The hypothesis I assumes that the intrapart antibiotic prophylaxis was administered to women colonized with GBS more than 4 hours before delivery. The hypothesis II presumes that newborns of GBS positive mothers who had been administered the antibiotic prophylaxis at least 4 hours before delivery were not colonized with GBS. The quantitative research was used to verify or reject the hypotheses. It was carried out by the retrospective analysis of medical records of women who gave birth between 1 June 2006 and 8 August 2007 at the maternity hospital in České Budejovice and had been colonized with GBS. The purpose of this thesis is to evaluate the antibiotic prophylaxis carried out in the maternity hospital in České Budejovice and to introduce the conclusions into practice and training.
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