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Biocompatible polymer nanomaterials with dexamethasone tailored for anti-inflammation therapy
Starenko, Daniil ; Etrych, Tomáš (advisor) ; Indra, Radek (referee)
Chronic inflammatory diseases are very common and affect lives of many people around the world. Moreover, in long-term effect chronic inflammation can lead to the development of such complications as diabetes, atherosclerosis and oncological diseases. Temporary therapy does not lead to complete recovery of a patient, but can provide a relief of symptoms by means of immunosuppression, which causes many adverse effects, because of long-term and nonselective drug activity. Application of the polymeric drug delivery systems is one of the actively researched ways for the improvement of inflammatory diseases treatment quality, which enables longer circulation, better distribution and controlled release of the drug. Dexamethasone is one of the commonly used glucocorticoid drugs used for treatment of chronic inflammatory diseases. Properties of this drug can be enhanced via polymeric drug delivery systems. Recently, so-called biological treatment, particularly employing monoclonal antibodies, against inflammation was introduced into the clinical use. One of such is infliximab - chimeric monoclonal antibody, which acts like the inhibitor of tumor necrotizing factor α (TNF-α). Presented bachelor thesis focuses on the synthesis and characterization of a polymer conjugates based on...
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