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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Metabolic and structural differences in primary aldosteronism and essential hypertension
 Šomlóová, Zuzana ; Widimský, Jiří (advisor) ; Mlíková Seidlerová, Jitka (referee) ; Červenka, Luděk (referee)
Hypertension is a major risk factor for cardiovascular (CV) disease, and patients with primary aldosteronism (PA) - the most common endocrine cause of hypertension - have a higher incidence of CV complications. The aim of this study was to evaluate the incidence of metabolic differences and organ complications - kidney, heart and blood vessels damage in patients with essential hypertension (EH), PA and its most common forms - idiopathic hyperaldosteronism (IHA) and aldosterone-producing adenoma (APA). We found a higher incidence of metabolic syndrome and a higher incidence of metabolic abnormalities in IHA compared to APA - higher prevalence of metabolic syndrome, higher levels of triglycerides and lower levels of HDL cholesterol and thereby a higher cardiometabolic risk. Metabolic profile of patients with IHA is similar to EH in contrast to APA. Arterial stiffness was expressed as pulse wave velocity (PWV), in central arteries as carotid-femoral PWV and at peripheral level as femoral-ankle PWV. Patients with PA with comparable levels of blood pressure (BP) have higher stiffness of central elastic and peripheral muscular arteries than patients with EH. The main predictor of impaired peripheral arterial stiffness is the plasma aldosterone level. Patients with IHA have higher central arterial...
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Laboratory Diagnosis of Primary Aldosteronism
 Hulová, Dagmar ; Martínková, Markéta (advisor) ; Bárta, František (referee)
Primary aldosteronism is a common form of endocrine hypertension, characterized by inappropriate production of aldosterone by the adrenal cortex, usually because of the unilateral adenoma (APA) or bilateral hyperplasia (IHA). The aim of this study was answer the question, if it is possible to distinguish APA from IHA with the use of the postural or the confirmatory test. From the laboratory results of the postural test, it was found that for the differentiation between the two most common forms of primary hyperaldosteronism APA and IHA is the postural test unusable in most cases. By the confirmation test was confirmed that there is not suppression of aldosterone after the administration of the saline solution to patients with primary aldosteronism below 100 ng∙l-1 in most cases (for APA in 85 %, for IHA in 65 %), in the remaining cases the value of the aldosterone do not decrease below 50 ng∙l-1 A higher value of the aldosterone in APA after the administration of the saline solution in the confirmation test could be considered a laboratory indicator of overproduction in APA.
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