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Group exercise with elements of Pilates method in individuals with ankylosing spodylitis - comparison with control group
Bendzová, Pavlína ; Levitová, Andrea (advisor) ; Majorová, Simona (referee)
Title: Group exercise with elements of the method Pilates in individuals with ankylosing spondylitis - comparisons with the control group Objective: Find impact of group therapy with engaging Pilates method to movability of axial system, functional status, activity of disease and total health status of individuals with ankylosing spondylitis. Compare this method with compensation group motion program in individuals with ankylosing spondylitis. Methods: 26 individuals with ankylosing spondylitis of average age (38,25 ± 9,18) attending Institute of Rheumatology in Prague were chosen. Probands were split into two groups: experimental group, which were doing motion program with elements of Pilates (n=13), and control group, which were attending compensation group motion program in individuals with ankylosing spondylitis. It was empirical quantitative research, exactly comparative quasiexperiment, where was compared individual groups in between (inter-group) and, moreover, influence of individual motion programs (intra-group). Data gathering was executed twice - at the beginning of quasiexperiment (pre-test) and at the end (3 months after; post-test). Those parameters were examined: Bath Ankylosing Spondylitis Metrology Index for axial system region and expansion of chest, Bath Ankylosing Spondylitis...
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Bone remodeling in rheumatic diseases: Bone loss in juvenile idiopathic arthritis
Brábníková Marešová, Kristýna ; Štěpán, Jan (advisor) ; Blahoš, Jaroslav (referee) ; Hrnčíř, Zbyněk (referee)
Introduction: The inflammation plays the essential role in the bone loss in juvenile idiopathic arthritis (JIA). Proinflammatory cytokines and also glucocorticoids (GCs) may activate bone resorption by osteoclasts. Simultaneously, bone formation can be attenuated, especially by inhibitors of proteins, which control the osteoblast differentiation. The aim was to verify the hypothesis that in patients with highly active JIA, reduction of bone formation via Wingless (Wnt) proteins inhibitors - Dickkopf 1 (Dkk-1) and sclerostin could be found. Except the densitometry measurements of bone and lean mass, we assessed markers of disease activity, bone metabolism and remodeling in young adult patients with JIA before and during 2 years of anti TNFα (tumour necrosis factor α) treatment, which decreases disease activity. Results: In patients with JIA before antiTNFα treatment, bone mineral density (BMD, g/cmš) was significantly reduced compared to controls. Values of BMD and body composition in JIA significantly depended on disease duration and GCs treatment. Serum concentration of sclerostin was significantly elevated in JIA compared to values in healthy controls. Values of the other monitored markers did not differ between JIA and controls. In patients with JIA, Dkk-1 correlated positively with C-reactive...
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Bone remodeling in rheumatic diseases: Bone loss in juvenile idiopathic arthritis
Brábníková Marešová, Kristýna ; Štěpán, Jan (advisor) ; Blahoš, Jaroslav (referee) ; Hrnčíř, Zbyněk (referee)
Introduction: The inflammation plays the essential role in the bone loss in juvenile idiopathic arthritis (JIA). Proinflammatory cytokines and also glucocorticoids (GCs) may activate bone resorption by osteoclasts. Simultaneously, bone formation can be attenuated, especially by inhibitors of proteins, which control the osteoblast differentiation. The aim was to verify the hypothesis that in patients with highly active JIA, reduction of bone formation via Wingless (Wnt) proteins inhibitors - Dickkopf 1 (Dkk-1) and sclerostin could be found. Except the densitometry measurements of bone and lean mass, we assessed markers of disease activity, bone metabolism and remodeling in young adult patients with JIA before and during 2 years of anti TNFα (tumour necrosis factor α) treatment, which decreases disease activity. Results: In patients with JIA before antiTNFα treatment, bone mineral density (BMD, g/cmš) was significantly reduced compared to controls. Values of BMD and body composition in JIA significantly depended on disease duration and GCs treatment. Serum concentration of sclerostin was significantly elevated in JIA compared to values in healthy controls. Values of the other monitored markers did not differ between JIA and controls. In patients with JIA, Dkk-1 correlated positively with C-reactive...
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Group exercise with elements of Pilates method in individuals with ankylosing spodylitis - comparison with control group
Bendzová, Pavlína ; Levitová, Andrea (advisor) ; Majorová, Simona (referee)
Title: Group exercise with elements of the method Pilates in individuals with ankylosing spondylitis - comparisons with the control group Objective: Find impact of group therapy with engaging Pilates method to movability of axial system, functional status, activity of disease and total health status of individuals with ankylosing spondylitis. Compare this method with compensation group motion program in individuals with ankylosing spondylitis. Methods: 26 individuals with ankylosing spondylitis of average age (38,25 ± 9,18) attending Institute of Rheumatology in Prague were chosen. Probands were split into two groups: experimental group, which were doing motion program with elements of Pilates (n=13), and control group, which were attending compensation group motion program in individuals with ankylosing spondylitis. It was empirical quantitative research, exactly comparative quasiexperiment, where was compared individual groups in between (inter-group) and, moreover, influence of individual motion programs (intra-group). Data gathering was executed twice - at the beginning of quasiexperiment (pre-test) and at the end (3 months after; post-test). Those parameters were examined: Bath Ankylosing Spondylitis Metrology Index for axial system region and expansion of chest, Bath Ankylosing Spondylitis...
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