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The influence of thyroid hormones and adrenal glands on mental function
Augustinová, Jana ; Šivicová, Gabriela (advisor) ; Špinka, Marek (referee)
This thesis focuses on effects of thyroid and adrenal hormones on mental functions, especially on cognitive functions and emotions. In the case of adrenal hormones it will also focus on stress and burnout syndrome, which are not considered as mental functions, but are connected to both psyche and the above mentioned hormones. The text is divided into two parts. The first, theoretical part deals with the anatomy and histology of these two organs, hormones that they produce and their influence on overall physical condition and pathology. The main section of this theoretical part deals with the description of influence of thyroid hormones and adrenal glands on the above mentioned mental functions. This work is based on both earlier and contemporary research, but predominantly on foreign research. In the second, empirical part, a proposal for longitudinal study of cortisol and thyroxine levels during depression treatment is presented. Klíčová slova: Hormones, thyroid glang, adrenal gland, mental functions, cognitive functions, emotions, stress, cortisol, thyroxine
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The influence of thyroid hormones and adrenal glands on mental function
Augustinová, Jana ; Šivicová, Gabriela (advisor) ; Špinka, Marek (referee)
This thesis focuses on effects of thyroid and adrenal hormones on mental functions, especially on cognitive functions and emotions. In the case of adrenal hormones it will also focus on stress and burnout syndrome, which are not considered as mental functions, but are connected to both psyche and the above mentioned hormones. The text is divided into two parts. The first, theoretical part deals with the anatomy and histology of these two organs, hormones that they produce and their influence on overall physical condition and pathology. The main section of this theoretical part deals with the description of influence of thyroid hormones and adrenal glands on the above mentioned mental functions. This work is based on both earlier and contemporary research, but predominantly on foreign research. In the second, empirical part, a proposal for longitudinal study of cortisol and thyroxine levels during depression treatment is presented. Klíčová slova: Hormones, thyroid glang, adrenal gland, mental functions, cognitive functions, emotions, stress, cortisol, thyroxine
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Circadian regulation of glucocorticoid secretion
Tejkal, Karel ; Sumová, Alena (advisor) ; Soták, Matúš (referee)
Glucocorticoids belong to a family of steroid hormones synthesized in the adrenal gland. They fulfill a variety of functions related to metabolism, immune response and ontogenesis. Glucocorticoids function as the end-effector of hypothalamic-pituitary-adrenal (HPA) axis and as such, their levels in blood are elevated after exposure to stressors. The basal levels of glucocorticoid also show a pronounced diurnal rhythm, suggesting involvement of the circadian clock in the regulation of HPA axis. Studies have shown that other regulatory mechanisms apart from the HPA axis are involved in regulation of diurnal glucocortioid secretion. The disturbances of the regulatory mechanisms may lead to serious pathological conditions. This thesis describes the rhythmic nature of glucocorticoid release and mechanisms by which the circadian clock exerts its influence over the rhythm. Thereafter, the feedback of glucocorticoids onto the clock system is briefly explained. Finally, some examples of a role of abnormal glucocorticoid secretion in selected pathologies are provided.
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