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Bioinformatics of human genome
Kupková, Karolína ; Provazník, Ivo (referee) ; Maděránková, Denisa (advisor)
Bachelor thesis deals with DNA segments containing only adenine and guanine. The theoretical part describes the structure and composition of deoxyribonucleic acid, chromosomes and genes. There are basic informations about chimpanzees and the human genome and conformations of the chains containing adenine with guanine. The practical part consists of a program that searches for the required sections in sequence, it displays and saves it. The thesis includes analysis of genes which are common for humans and chimpanzees, which were analyzed to determine randomness, functionality a preserving of these sections.
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Searching adenine and guanine rich regions
Vlachynská, Alžběta ; Provazník, Ivo (referee) ; Maděránková, Denisa (advisor)
This work deals with searching adenine and guanine rich regions. Their finding which determines the randomness and functionality may lead to better understanding genetic data storage in DNA sequences. The first part of the work describes the chemical composition and structure of DNA, its replication, transcription and translation. It contains the basic information about the genome. The next chapter deals with numerical representation of DNA sequences, necessary for a computer processing. Nucleotide density is a method suitable for searching adenine and guanine rich regions. The practical part of the work is an application designed and implmented in MATLAB environment. The last part is the analysis of human, chimpanzee and mice genes.
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Electrochemical detection of purine bases using thick film Cu2O electrodes
Gabriel, Petr ; Prášek, Jan (referee) ; Pekárková, Jana (advisor)
This work deals with the production process thick films electrodes. It is focused on the Cu2O working electrodes preparation by screen printing and spray coating - methods on the corundum substrate. In this work are described both methods of fabrication and basic electrochemical methods. Prepared Cu2O electrodes were used for electrochemical detection of purine bases (adenine, guanine) using cyclic voltammetry. The effect of pH on the detection of purines was also examines.
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Searching adenine and guanine rich regions
Vlachynská, Alžběta ; Provazník, Ivo (referee) ; Maděránková, Denisa (advisor)
This work deals with searching adenine and guanine rich regions. Their finding which determines the randomness and functionality may lead to better understanding genetic data storage in DNA sequences. The first part of the work describes the chemical composition and structure of DNA, its replication, transcription and translation. It contains the basic information about the genome. The next chapter deals with numerical representation of DNA sequences, necessary for a computer processing. Nucleotide density is a method suitable for searching adenine and guanine rich regions. The practical part of the work is an application designed and implmented in MATLAB environment. The last part is the analysis of human, chimpanzee and mice genes.
|
|
|
Electrochemical detection of purine bases using thick film Cu2O electrodes
Gabriel, Petr ; Prášek, Jan (referee) ; Pekárková, Jana (advisor)
This work deals with the production process thick films electrodes. It is focused on the Cu2O working electrodes preparation by screen printing and spray coating - methods on the corundum substrate. In this work are described both methods of fabrication and basic electrochemical methods. Prepared Cu2O electrodes were used for electrochemical detection of purine bases (adenine, guanine) using cyclic voltammetry. The effect of pH on the detection of purines was also examines.
|
|
|
Bioinformatics of human genome
Kupková, Karolína ; Provazník, Ivo (referee) ; Maděránková, Denisa (advisor)
Bachelor thesis deals with DNA segments containing only adenine and guanine. The theoretical part describes the structure and composition of deoxyribonucleic acid, chromosomes and genes. There are basic informations about chimpanzees and the human genome and conformations of the chains containing adenine with guanine. The practical part consists of a program that searches for the required sections in sequence, it displays and saves it. The thesis includes analysis of genes which are common for humans and chimpanzees, which were analyzed to determine randomness, functionality a preserving of these sections.
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