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QSAR Analysis of the Acute Toxicity Indices Determined by Alternative Methods
Kanásová, Mária ; Rucki, Marian (advisor) ; Dvořáková, Markéta (referee)
1 Abstract The goal of the thesis is to determine acute toxicity indices of seven alcohols (2-ethoxyethanol, 1-propanol, 3-methyl-1-butanol, 3-methyl-2-butanol, 3-hexanol, 2-methyl-3-hexanol, 1-nonanol) by two different alternative methods. Another goal is to create QSAR models to predict the acute toxicities of alcohols which belong into model limits. First of the methods used is based on the movement inhibition of lower animals Tubifex tubifex. The method provides the acute toxicity indices EC50. The second method uses the cell line of mouse fibroblasts called Balb/c 3T3 and it provides the acute toxicity indices IC50. The IC50 were recalculated to the LD50 values that correspond to the oral administration of alcohols to a rat. It has been found that 1-nonanol is included into the category of alcohols classified as acute oral toxic according to the EU CLP system. Other six alcohols are non-classified as acute oral toxic. Subsequently, accurate QSAR models has been created in order to predict the acute toxicity of other alcohols using Tubifex tubifex specie or Balb/c 3T3 cell line. The models are suitable for saturated, branched, ethoxy- and cyclic alcohols with the log POW value from −0.74 to 3.07. It was necessary to exclude the acute toxicity indices of 1-nonanol from these models as some solubility...
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QSAR Analysis of the Acute Toxicity Indices Determined by Alternative Methods
Kanásová, Mária ; Rucki, Marian (advisor) ; Dvořáková, Markéta (referee)
1 Abstract The goal of the thesis is to determine acute toxicity indices of seven alcohols (2-ethoxyethanol, 1-propanol, 3-methyl-1-butanol, 3-methyl-2-butanol, 3-hexanol, 2-methyl-3-hexanol, 1-nonanol) by two different alternative methods. Another goal is to create QSAR models to predict the acute toxicities of alcohols which belong into model limits. First of the methods used is based on the movement inhibition of lower animals Tubifex tubifex. The method provides the acute toxicity indices EC50. The second method uses the cell line of mouse fibroblasts called Balb/c 3T3 and it provides the acute toxicity indices IC50. The IC50 were recalculated to the LD50 values that correspond to the oral administration of alcohols to a rat. It has been found that 1-nonanol is included into the category of alcohols classified as acute oral toxic according to the EU CLP system. Other six alcohols are non-classified as acute oral toxic. Subsequently, accurate QSAR models has been created in order to predict the acute toxicity of other alcohols using Tubifex tubifex specie or Balb/c 3T3 cell line. The models are suitable for saturated, branched, ethoxy- and cyclic alcohols with the log POW value from −0.74 to 3.07. It was necessary to exclude the acute toxicity indices of 1-nonanol from these models as some solubility...
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Influence of humic substance HS 1500 on tolerance of Sterlet to nitrite
BULÍČEK, Vojtěch
The aim of the thesis was to assess the effect of humic substance HS 1500 on the tolerance of Sterlet (Acipenser ruthenus) to nitrite. Preparation Huminfeed was used as a source of substance HS 1500. Tolerance of Sterlet to nitrite was assessed on the basis of the results of acute toxicity tests and the results of haematological and biochemical blood examination of fish that were exposed to increased concentrations of nitrite in the presence and absence of preparation Huminfeed.
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Alternativní metoda pro stanovení akutní toxicity chemických látek a odhad akutní toxicity jejich směsí
Státní zdravotní ústav, Praha ; Výzkumný ústav organických syntéz, Centrum ekologie, toxikologie a analytiky, Pardubice-Rybitví ; Tichý, Miloň
Úkolem projektu bylo zjistit, zda údaje o akutní toxicitě, měřené v testech na obratlovcích, lze odhadnout výpočtem z údajů o akutní toxicitě, získaných na nižších organismech, případně z fyzikálně-chemických vlastností chemikálií.
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Hodnocení rizika vybraných chemických látek vyráběných nebo dovážených do ČR
Výzkumný ústav organických syntéz, Centrum ekologie, toxikologie a analytiky, Pardubice-Rybitví ; Petira, Oldřich ; Mejstřík, Viktor ; Krejsová, Hana ; Koryntová, Ilona ; Držková, Libuše ; Doležalová, Ludmila ; Čihák, Rostislav
Svazek obsahuje přílohu 3: Alternativní zkušební test pro hodnocení žíravosti chemických látek a přípravků a přílohu 4: Pilotní zkoušky vybrané chemikálie.
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Toxicity of selected substances for spiny-cheek crayfish
MAHOVSKÁ, Ivana
The thesis examined the toxicity of selected compounds for spiny-cheek crayfish (Orconectes limosus) in laboratory conditions. Tested the acute toxicity of the insecticide Diazinon 60 EC and herbicide Roundup Biaktiv. Tests were chosen to juveniles spiny-cheek crayfish (Orconectes limosus), and juvenile and adult specimens of signal crayfish (Pacifastacus leniusculus).These species of crayfish have been selected as an easily accessible model organism. Both species of crayfish spreading and in Europe they are unoriginal. Work focused on the observed toxicity of these substances on spiny-cheek crayfish and signal crayfish and the demands on the quality of the environment.
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