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Rapidly mutating Y-STRs analysis as a tool for forensic investigations, genetic genealogical applications and molecular anthropology
Jakub, David ; Šimková, Halina (advisor) ; Doubková, Klára (referee)
Compared to standard Y-STR markers commonly used in forensics and bioarchaeology, rapidly mutating Y-STR markers (RM Y-STR) have a significantly higher haplotype diversity and lineage resolution abilities in world populations. They form a novelty in these fields. This paper will attempt to clarify their origin, function, and efficacy in forensic genetics, genealogy, and molecular anthropology by looking at the Y chromosome and its characteristics that allow its use in the mapping of populations, individual male lineages, and identifying male perpetrators of sexual violence. By looking at other polymorphisms of the Y chromosome, especially Y-SNP markers, we can see in which studies each type is used most effectively. In the end, it will be clarified whether the use of RM Y-STR markers is beneficial to each field, whether they make standard Y-STR markers redundant, or whether they are themselves of no substantial use in comparison.
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Y Chromosomal Characteristics of the Modern Rural Population in Klatovy Region
Doležalová, Veronika ; Ehler, Edvard (advisor) ; Stenzl, Vlastimil (referee)
Usage of genetic markers in non-recombining part of chromosome Y has been shown as a eligible tool for a study of history, diversity and migration of population. Applicable markers of chromosome Y are SNP and STR polymorphisms. There were collected 53 unique samples of DNA as a object of this work from unrelated origin males from 9 villages around Klatovy. Samples have been analyzed and its values have been determined by using the 17 STR markers by AmpFLSTR® Yfiler® Direct Kit. In total I have observed 7 different haplogroups. I have resulted samples from villages around Klatovy and they were analyzed by AMOVA. I have compared samples with the surrounding populations in neighborly Federal Republic of Germany, Austria, Central and South Bohemia. There were no significant differences founded in the genetic profile of this population to the surrounding populations.
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Y Chromosomal Characteristics of the Modern Rural Population in Klatovy Region
Doležalová, Veronika ; Ehler, Edvard (advisor) ; Stenzl, Vlastimil (referee)
Usage of genetic markers in non-recombining part of chromosome Y has been shown as a eligible tool for a study of history, diversity and migration of population. Applicable markers of chromosome Y are SNP and STR polymorphisms. There were collected 53 unique samples of DNA as a object of this work from unrelated origin males from 9 villages around Klatovy. Samples have been analyzed and its values have been determined by using the 17 STR markers by AmpFLSTR® Yfiler® Direct Kit. In total I have observed 7 different haplogroups. I have resulted samples from villages around Klatovy and they were analyzed by AMOVA. I have compared samples with the surrounding populations in neighborly Federal Republic of Germany, Austria, Central and South Bohemia. There were no significant differences founded in the genetic profile of this population to the surrounding populations.
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