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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Preparation of titanium and zirconium metallocene complexes with pendant nitrile groups
 Večeřa, Miloš ; Štěpnička, Petr (advisor) ; Vojtíšek, Pavel (referee)
Preparation of metallocene complexes of titanium and zirconium with pendant nitrile groups Miloš Večeřa bachelor thesis Abstract: Two cyclopentadienide salts with pendant nitrile groups were prepared in the form of their corresponding lithium salts and these salts were utilized for the preparation of titanium and zirconium metallocene complexes. One of the ligands was already described in the literature, while the other as well as all the prepared group 4 metallocene complexes are new compounds. Starting materials for these syntheses were 6,6-dimethylfulvene and spiro[2.4]hepta-4,6-diene which, upon a nucleophilic attack by 2-lithio-2-methylpropanenitrile, afforded the corresponding substituted lithium cyclopentadienides, which were characterized by 1 H and 13 C NMR spectroscopy and infrared spectroscopy. Then lithium salts were reacted with Cp*TiCl3 and Cp*ZrCl3 to give the corresponding metallocene dichlorides. Solid-state structures of the prepared titanocene dichlorides were elucidated by means of single crystal X-ray diffraction analysis. The obtained structures allowed a comparison with the known structures of the previously prepared homologous derivative. Unfortunately the corresponding zirconocene dichlorides did not crystallize. Moreover, all the newly prepared metallocenes were characterized by 1...
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Structure Analysis of Plant Bifunctional Nuclease TBN1
 Kovaľ, Tomáš ; Dohnálek, Jan (advisor) ; Brynda, Jiří (referee) ; Schneider, Bohdan (referee)
This work is dedicated to thorough structural analysis of plant bifunctional nuclease TBN1, the representative of plant nuclease I group. TBN1 along with homologous nucleases from this family plays an important role in plant cell life cycle and also shows considerable anticancerogenic effects. Two variants of TBN1 (wild type and N211D mutant) were studied. Properties of both variants in different solutions were analyzed. Both were successfully crystallized. Structures of both types of TBN1 were solved using X-ray diffraction. The phase problem was solved by Multi-wavelength anomalous dispersion using Zn2+ ions natively present in TBN1. Structural properties of TBN1 such as fold, active site composition, effect of glycosylation and surface electrostatic potential distribution were analyzed. Reaction mechanism of TBN1 was proposed on the basis of structural properties and comparisons with similar structures.
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