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Glycolytic enzymes and their inhibition in cancer cell invasiveness
Martinková, Eliška ; Peltanová, Barbora (advisor) ; Raudenská, Martina (referee)
Glycolysis, an essential metabolic pathway, serves to obtain energy from glucose. All ten enzymes, which are part of the glycolytic pathway, may be involved in processes that influence migration and the ability of tumor cells to invade surrounding tissues, which is closely related to the formation of metastases. Since the majority of patients with diagnosed solid tumors die because of complications associated with primary tumor metastases, studying this phenomenon is of great interest. The purpose of this thesis is to summarize the findings on the relationship between glycolytic enzymes and tumor cell invasion. Diverse roles of enzymes related to invasion, migration and metastases are described herein, ranging from influencing angiogenesis, cytoskeleton formation and mRNA and protein stabilization to affecting various signal cascades. Room is devoted not only to the relevant mechanisms at the molecular level but also to the results of research focused on therapy to date. The thesis also provides an overview of selected inhibitors of glycolytic enzymes that affect tumor cells invasion. Key words: invasion, migration, metastasis, glycolytic enzymes, inhibition, EMT, Warburg effect
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Mitochondrial dysfunction in brain tumors
Rollerová, Kateřina ; Vaňátko, Ondřej (advisor) ; Zobalová, Renata (referee)
Brain tumors are one of the most serious pathologies of the central nervous system. Brain tumors are aggressive and very hard to treat due to the fragile nature of the nervous system, presence of blood-brain barrier and high recurrence rate. One of the hallmarks of brain tumors is mitochondrial dysfunction. Mitochondria are organelles involved in essential cellular processes, such as energy production, redox and calcium signaling, or the regulation of cell death. Structural and functional abnormalities, mutations in the mitochondrial genome and other mitochondrial dysregulations may cause disruptions in various cellular processes, such as production of reactive oxygen species, migration, proliferation, or regulation of cell death, promoting the development and/or maintenance of brain tumors. The goal of this thesis is to summarize current knowledge about mitochondrial dysfunction in brain tumors. Key words: brain tumors; mitochondria; mitochondrial dysfunction; Warburg effect; apoptosis; reactive oxygen species; isocitrate dehydrogenase
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