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The role of uncoupling proteins (UCP) in cardioprotection
Furmánková, Tereza ; Horníková, Daniela (advisor) ; Adamcová, Kateřina (referee)
Cardiovascular disease (CVD) is the world's leading cause of death. Almost 18 million people die of CVD each year, and the prevalence continues to rise for both men and women. It is now clear that the maintenance of mitochondrial membrane potential can play an important role in the pathophysiology of the heart and it is involved in cardioprotective mechanisms. Mitochondrial membrane potential can be affected in a various of ways, one of them is the stimulation of uncoupling proteins. An elaboration of previous findings in this work has shown that uncoupling proteins have the effect of reducing oxygen radicals, inhibiting apoptosis, affect the production of ATP and atherosclerotic plaques and protect the heart from lipid toxicity. There are several ways to regulate their gene expression, and influencing these pathways may be a way to achieve cardioprotection. Key words: uncoupling proteins, mitochondria, cardioprtoection, thyroid hormones, fatty acids, adipose tissue, reactive oxygen species, FGF21
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The role of uncoupling proteins (UCP) in cardioprotection
Furmánková, Tereza ; Horníková, Daniela (advisor) ; Adamcová, Kateřina (referee)
Cardiovascular disease (CVD) is the world's leading cause of death. Almost 18 million people die of CVD each year, and the prevalence continues to rise for both men and women. It is now clear that the maintenance of mitochondrial membrane potential can play an important role in the pathophysiology of the heart and it is involved in cardioprotective mechanisms. Mitochondrial membrane potential can be affected in a various of ways, one of them is the stimulation of uncoupling proteins. An elaboration of previous findings in this work has shown that uncoupling proteins have the effect of reducing oxygen radicals, inhibiting apoptosis, affect the production of ATP and atherosclerotic plaques and protect the heart from lipid toxicity. There are several ways to regulate their gene expression, and influencing these pathways may be a way to achieve cardioprotection. Key words: uncoupling proteins, mitochondria, cardioprtoection, thyroid hormones, fatty acids, adipose tissue, reactive oxygen species, FGF21
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Documentary Letter of Credit like a Securing Instrument
Štěpánková, Lenka ; Černohlávková, Eva (advisor) ; Nejedlý, Michal (referee)
My thesis deals with documentary letter of credit and with its use in the international trade. The first part of my work is focused on the definition of documentary letter of credit and on the relations between parties acting in the documentary credit operation. The second chapter describes types of letters of credit and, finally, the third chapter, the core of this thesis, focuses on the transactions carried out using a letter of credit and on the practical procedure of the transaction. There are also described the advantages and disadvantages of the documentary letter of credit and its use considering the recent financial crisis and current trends in the international trade.
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