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Profiling of T-cell receptor rearrangements in type 1 diabetes and celiac disease research
Obermaierová, Anna ; Froňková, Eva (advisor) ; Volejníková, Jana (referee)
This thesis discusses the detection of T-lymphocyte receptor rearrangements (TCR) with NGS methods and its significance in autoimmune disorders such as type 1 diabetes (T1D) and celiac disease. The first part introduces sequencing methods of TCRs and highlights the breakthrough that came with the advent of NGS. The second part then describes various approaches to utilizing these methods in medicine, with special attention dedicated to the endeavour of finding biomarkers for two closely related autoimmune disorders: T1D and celiac disease.

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