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Influence of conditions on hydrogel preparation
Heger, Richard ; Kalina, Michal (referee) ; Mravec, Filip (advisor)
This work is focused on testing the influence of conditions, more precisely pH, during the creation of hydrogels that were prepared through the hydration of powdery mixtures, by another name solid-mixture way. The hydrogel system was made from a polyelectrolyte, more accurately sodium hyaluronate and a cationic surfactant, CTAB. The influence of pH was studied through observation and rheology. For measuring purposes, the hyaluronan with the molecular weight of 600-800 kDa was used. The system was examined via a series of buffers with the pH of 3,5-11. The gels were dyed by Sudan III for better observability and description. It was found that the best way of adding an active substance was by adding a dye directly into a powdery mixture. The observed properties of the gels didn’t change even after the gels were modified to the ionic strength of a physiological saline solution (0,15 M).
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Influence of conditions on hydrogel preparation
Heger, Richard ; Kalina, Michal (referee) ; Mravec, Filip (advisor)
This work is focused on testing the influence of conditions, more precisely pH, during the creation of hydrogels that were prepared through the hydration of powdery mixtures, by another name solid-mixture way. The hydrogel system was made from a polyelectrolyte, more accurately sodium hyaluronate and a cationic surfactant, CTAB. The influence of pH was studied through observation and rheology. For measuring purposes, the hyaluronan with the molecular weight of 600-800 kDa was used. The system was examined via a series of buffers with the pH of 3,5-11. The gels were dyed by Sudan III for better observability and description. It was found that the best way of adding an active substance was by adding a dye directly into a powdery mixture. The observed properties of the gels didn’t change even after the gels were modified to the ionic strength of a physiological saline solution (0,15 M).
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