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National Repository of Grey Literature 3 records found  Search took 0.01 seconds. 
Elucidating the source of bloodstream \kur{Trypanosoma brucei} mitochondrial ATP
 HUSOVÁ, Michaela
For decades, it has been assumed that the reduced function and structure of the bloodstream form Trypanosoma brucei mitochondrion renders it a strictly ATP consuming organelle. Emerging evidence from refocused studies suggest that the bloodstream mitochondrion retains complex bioenergetic pathways that allow the parasite to adapt to various environments. This thesis is focused on the source of bloodstream mitochondrial ATP, with a special emphasis on the role of succinyl-CoA to produce ATP via mitochondrial substrate phosphorylation. We will also discuss alternative bioenergetic pathways present in this life stage of a human pathogen.
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The role of mitochondrial SCoAS substrate-level phosphorylation in the bloodstream form \kur{T. brucei}
 HUSOVÁ, Michaela
Mitochondrial metabolism of Trypanosoma brucei is considered highly reduced because of its dysfunctional electron transport chain and tricarboxylic acid cycle. But previously published paper suggests significant mitochondrial ATP pool created by substrate phosphorylation via succinyl coenzyme A synthetase, which plays crucial role in T. brucei survival. This thesis is therefore focused on substrate phosphorylation and on influence of succinyl coenzyme A synthetase heterodimer RNAi on T. brucei cells.
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Analysis of Mitochondrial Bioenergetics of Bloodstream Form of Trypanosoma Brucei
 IELANSKYI, Mykyta
Trypanosoma brucei is a pleomorphic extracellular parasite that represents significant scientific interest due to its early divergence from the eukaryotic lineage and its range of unique adaptations. Among these adaptions are some metabolic pathways that are unconventional and are not fully understood. Among such pathways are the catabolic pathways of the parasite's bloodstream form, in particular those responsible for ATP supply to the parasites' reduced mitochondrion. This thesis investigates the nature of these pathways as well as interactions between them.
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