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Psychometric characteristics of Subjective cognitive changes questionnaire in the elderly at the risk of developing dementia syndrome
Zuntychová, Terezie ; Horáková, Hana (advisor) ; Bezdíček, Ondřej (referee)
This Master's thesis focuses on subjective cognitive complaints (SCC) in the elderly as one of the very early cognitive markers of Alzheimer's disease (AD). The literature review section maps cognitive impairment in the old age and complements it with an overview of successful cognitive ageing, subjective cognitive decline (SCD) and relevant neurobiological correlates. It also describes the knowledge about the variety of causes of SCD, their assessment and the terminology used. This is followed by quantitative research (n = 211) that elaborates selected psychometric characteristics of the newly constructed Subjective Cognitive Changes Questionnaire (SCC-Q). The research population included patients with amnestic mild cognitive impairment (aMCI; n = 88), SCD (n = 88), and cognitively normal volunteers (n = 35). Based on the statistical analyses performed, high item reliability was verified, a four- component solution of the SCC-Q structure was adopted, and support for convergent validity of three of the four components was subsequently found. Thus, the SCC-Q has the potential to become a useful method for clinical practice. The thesis further discusses follow-up procedures to validate the SCC-Q to identify individuals at risk of developing cognitive deficits. Keywords Subjective cognitive...

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