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Determination of cortisol in saliva
Žánová, Magdalena ; Martínková, Markéta (advisor) ; Milichovský, Jan (referee)
This thesis deals with salivary cortisol levels measured by the ADVIA: Centaur CP Immunoassay System. Experimental saliva sampling was performed on 141 pro- bands from age 7 to 76. Volunteers were divided to groups according to their sex: males, females using hormonal contraceptives (HC) and females not using HC. Re- ference intervals of morning and evening salivary cortisol were defined: females not using HC 13,2 - 55,5 nmol/l and females using HC 15,5 - 44,2 nmol/l for mor- ning salivary cortisol. Females not using HC 4,0 - 16,6 nmol/l and females using HC 7,9 - 22,6 nmol/l for afternoon salivary cortisol. Males 15,8 - 47,7 nmol/l for morning salivary cortisol and 5,2 - 25,4 nmol/l for afternoon salivary cortisol. Dif- ferences in stated intervals were imperceptible in all monitored groups. However, it is necessary to maintain different reference intervals for both morning and evening sampling. Reference interval for morning sampling was 14,3 - 46,2 nmol/l and refe- rence interval for afternoon sampling was set at 4,0 - 22,2 nmol/l. Daily profiles of salivary cortisol were determined in 6 females and 4 males in four different parts of a day. The course of salivary cortisol levels corresponded in females not using HC, females using HC and males with circadian rhythm, which is subject to cortisol. Sa-...
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16-androstenes Anosmia in Men
Vondrová, Marta ; Havlíček, Jan (advisor) ; Martinec Nováková, Lenka (referee)
16-androstenes Anosmia in Men 16-androstens are compounds of steroid character which are secreted to the skin as part of apocrine glands secrets and they participate in creating body odor. It was found that androstenes influence affective state and psychophysiological reactions. The effect of androstenes can be also found on subliminal level. However, it has not yet been tested whether individuals with specific anosmia could also be influenced this way. Specific anosmia is described as an individual's incapability of conscious detection of particular odor while the detection of other compounds remains unaffected. The aim of the thesis is to test whether specifically anosmic individuals can be influenced by compounds to which they are anosmic to. This hypothesis is based on research of sensitization. Previous research indicates that olfactory perception may be of larger plasticity than thought. The theoretical part focuses on critical analysis of androstenes and research on specific anosmia. This field contains topics such as influence of chemical structure on androstenes perception, genetic influences, sensitization, functions of androstenes in interpersonal interactions and research on brain imagining. The experimental part focused on measuring subjective ratings of mood and psychophysiological...
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