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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
The role of Rorγt+ antigen presenting cells in peripheral tolerance to microbiota
 Arutsev, Savva ; Dobeš, Jan (advisor) ; Somova, Veronika (referee)
The intestinal immune system needs mechanisms that provide a balance between suppression and tolerance to microbiota, regulating beneficial and inhibiting pathogenic ones. One such mechanism is based on microbiota-specific Rorγt+ T regulatory cells (Tregs), which can regulate immunity upon recognition of a specific antigen. Rorγt+ antigen-presenting cells (APCs) have been hypothesized to promote microbiota-specific Tregs development, but the specific mechanism was poorly understood until recently. In my bachelor thesis I provide an introduction to Tregs biology, compare and review in detail studies indicating a possible role of lymphoid tissue inducers like group 3 innate lymphoid cells, Janus cells and newly discovered Thetis cells in the generation of Rorγt+ Tregs as well as a possible molecular mechanism based on the integrins Itgav and Itgb8.
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