|
|
The effect of phosphorylation in the regulation of Rho-GTPases
Novotná, Michaela ; Rösel, Daniel (advisor) ; Hála, Michal (referee)
This bachelor thesis is focused on regulating of the activity of the Rho GTPases. Rho GTPases are important signalling proteins that are involved in regulation of many cellular processes, for example dynamic cytoskeleton changes (especially actin fibres) associated with cell adhesion and migration, vesicle trafficking or cell cycle. The activity of the Rho GTPases is primarily regulated by other proteins affecting the presence GTP/GDP or by posttranslational modifications. This thesis is focused on a narrow section of these modifications, namely phosphorylations. Phosphorylation of the Rho GTPases affects for example their activity, localization, or degradation. Understanding the mechanism of regulation of Rho GTPase activity is important for comprehension of cellular processes. Rho GTPases are involved, for example, in tumour cell invasiveness. By studying Rho GTPases and their regulation, it is possible to better target potential treatment or even prevent the occurrence of the metastases.
|
guest ::
