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Biotransformation of monepantel in plant (Campanula rotundifolia, Plantago lanceolata)
Crhová, Anna ; Raisová Stuchlíková, Lucie (advisor) ; Vokřál, Ivan (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Anna Crhová Supervisor: RNDr. Lucie Stuchlíková Raisová, Ph.D. Title of diploma thesis: Biotransformation of monepantel in plants (Campanula rotundifolia, Plantago lanceolata) Anthelmintics are veterinary drugs used to eliminate disease caused by parasitic worms. Monepantel (MOP) is a representative of amino-acetonitrile derivatives. This relatively new group of drugs is effective on helminthic strains, which are resistant to classic therapy (benzimidazoles, makrocyklic lactones, imidazothiazoles). Due to high consuption of these drugs, it is important to find out their fate in the exposed organisms. Anthelmintics are in contact with the environment and they can affect terrestrial and aquatic organisms. Their various forms can be accumulate in plants. These plants can be eaten by the animal, which may lead to development of resistance in helminths. In addition, the physiology of plants and animals may be disrupt and, consequently, biodiversity loss may occur. The aim of this study was to determine the biotransformation processes occurring in ribwort plantain (Plantago lanceolata) and harebell (Campanula rotundifolia) after low concentrations of MOP. Suspensions of both plants cells...
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