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Study of interactions of betrixaban with antiretrovirals in an intestinal barrier model
Lukáčová, Ivana ; Vokřál, Ivan (advisor) ; Červený, Lukáš (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Ivana Lukáčová Supervisor: PharmDr. Vokřál Ivan, Ph.D. Title of diploma thesis: Study of interactions of betrixaban with antiretrovirals in an intestinal barrier model Oral administration of drugs is a practical and simple choice for the patient, which ensures high adherence to the treatment, and thanks to that, it is the most frequently used dosage form. The vast majority of these drugs penetrate intestinal barrier after oral administration, and many clinically significant drug interactions can occur right in this place. Several determinants, including membrane transport systems, have an impact on whether or not the effect is manifested. The most observed and studied transporter from the superfamily of ABC transporters in the small intestine is undoubtedly P-glycoprotein (P-gp). It functions as an efflux pump preventing the transfer of xenobiotics, including drugs, into the systemic circulation, thereby protecting the organism and thus creating a barrier against the possible toxic effect of substances. The direct-acting anticoagulant betrixaban is a substrate of P-gp in the intestinal barrier, and therefore simultaneous administration with drugs inhibiting or inducing this transporter can...
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