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Ovarian stimulation and related hyperstimulation syndrome
Pohlová, Nikola ; Komrsková, Kateřina (advisor) ; Ješeta, Michal (referee)
Ovarian stimulation is a key process of assisted reproduction and it helps women in the treatment of infertility. Hormonal ovarian stimulation ensures the growth and development of ovarian follicles. The selected dominant follicle releases an oocyte during ovulation, which is destined for fertilization. In methods of artificial fertilization, multiple follicles are stimulated, and more oocytes are retrieved. The retrieved oocytes are then fertilised in vitro. In this thesis, the benefits and risks of the commonly used stimulation protocols are discussed. The focus is on optimizing stimulation for individual patients, considering their health status, functional ovarian reserve, and individual needs. Special stimulation protocols for patients with polycystic ovary syndrome and for patients with cancer are presented. Ovarian stimulation is also applied to oocyte donors. The most serious risk of ovarian stimulation is ovarian hyperstimulation syndrome. Ovarian stimulation is also used in the rescue of endangered mammalian species or in the breeding of domesticated animals. The study of ovarian stimulation is important for the improvement of reproductive methods in human and veterinary medicine. Key words: follicles, ovarian stimulation, assisted reproduction, ovulation, risks
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Principles of ovarian stimulation and oocyte collection in mouse and human.
Klinovská, Karolína ; Hortová, Kateřina (advisor) ; Svoboda, Petr (referee)
This thesis deals with methods of controlled ovarian stimulation and oocyte retrieval on physiological basis. Mouse has been major model organism for wide range of key researches and being able to stimulate its ovarian functions correctly is necessary. That is why mouse stimulation is main topic of this thesis. It summarizes available data and stimulation protocols in relation to factors which can affect the result as a condition, strain, quality of hormones used in administration and others. Potential affections on oocyte and embryo quality are mention according to specific types of administration protocols. Human infertility is slowly becoming common and one of the techniques used to treat it in assisted reproduction is also ovarian stimulation. In the end of this thesis is a chapter dealing with this commonly used method. It is focused on stimulation for oocyte retrieval, as well as on stimulation of recipient mother in embryotransfer. Differences based on hormones, success in In vitro fertilization programme (IVF) and application frequency are mentioned.
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Principles of ovarian stimulation and oocyte collection in mouse and human.
Klinovská, Karolína ; Svoboda, Petr (referee) ; Hortová, Kateřina (advisor)
This thesis deals with methods of controlled ovarian stimulation and oocyte retrieval on physiological basis. Mouse has been major model organism for wide range of key researches and being able to stimulate its ovarian functions correctly is necessary. That is why mouse stimulation is main topic of this thesis. It summarizes available data and stimulation protocols in relation to factors which can affect the result as a condition, strain, quality of hormones used in administration and others. Potential affections on oocyte and embryo quality are mention according to specific types of administration protocols. Human infertility is slowly becoming common and one of the techniques used to treat it in assisted reproduction is also ovarian stimulation. In the end of this thesis is a chapter dealing with this commonly used method. It is focused on stimulation for oocyte retrieval, as well as on stimulation of recipient mother in embryotransfer. Differences based on hormones, success in In vitro fertilization programme (IVF) and application frequency are mentioned.
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