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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
The role of endocytosis in Wnt signaling pathway
 Matějů, Daniel ; Libusová, Lenka (advisor) ; Doubravská, Lenka (referee)
Endocytosis and cell signaling are tightly connected processes. This connection is most obvious at the level of endocytosis of signaling receptors and ligands. For many years, endocytosis of signaling receptors was considered as a negative feedback loop mechanism, which desensitizes the cell after prolonged stimulation by ligand. Now it is evident that the situation is more complex and endocytosis can affect cell signaling both negatively and positively. In this thesis, I will summarize how Wnt signaling can be affected by endocytosis of receptors and ligands of this signaling pathway. Wnt signaling is one of the most important and intensively studied signaling pathways in the metazoan development. Several possible roles of endocytosis in Wnt signaling were uncovered in recent years, some of them unique among other signaling pathways. Understanding the relationship between endocytosis and Wnt signaling will thus help not only to deepen the knowledge of Wnt signaling but also to shed light on the possible roles of endocytosis in regulation of cell signaling in general.
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