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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Chromatographic characterization of an ion-exchange column
 Štverková, Kateřina ; Sobotníková, Jana (advisor) ; Coufal, Pavel (referee)
This bachelor thesis deals with the characterization of the anion exchange column by the linear solvation energy relationship (LSER) model. The aim of this bachelor thesis was to find optimal conditions suitable for separation of thiazide diuretics (trichlormethiazide, bendroflumethiazide, buthizide, chlorthalidone, mefrusid) on PhenoSphereTM 5μm SAX 80 Ǻ column. These experimental conditions were used for measuring the retention factors of LSER analytes. The multiple linear regression was consequently applied to the retention factors to calculate the LSER regression coefficients, describing the interactions between the stationary phase, the mobile phase and the analytes.
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Chromatographic characterization of an ion-exchange column
 Seidlová, Bára ; Sobotníková, Jana (advisor) ; Křížek, Tomáš (referee)
The following evaluation procedure was selected for the charterized ion-exchange column Phenosphere™ SCX. First of all, a set of biologically interesting analytes was selected. This set contained several basic drugs, specifically five tricyclic antidepressants (TCA), an anesthetic called procaine and a substance with antimalaric and antiarrythmic effect - quinidine. For this set of basic substances were the separation conditions optimized on a characterized ion-exchange column Phenosphere™ SCX. The effect of the mobile phase composition on chromatographic behaviour of selected drugs was investigated, for instance the effect of used buffer and its concentration, buffer pH and the effect of addition of the organic modifier (in this case methanol). Under optimized chromatographic conditions for basic drugs analysis the ion-exchange column was characterized using LSER (Linear Solvation Energy Relationship). The chromatographic behaviour of the test substances with known molecular descriptors was found and then the multiple linear regression between retention factors of test substances and their molecular descriptors was done. The results of the multiple linear regression were discussed and then the interactions contributing to the analyte retention on the investigated cation-exchange column...
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