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Studium konformačních efektů vazby ligandu na proteinovou strukturu
Šefců, Oskar ; Novotný, Marian (advisor) ; Hexnerová, Rozálie (referee)
This bachelor thesis aims to provide a comprehensive overview of the effects of ligand binding on the 3D structure of proteins. The focus will be on examples where ligand binding causes a significant conformational change between the structure without the ligand (apo structure) and the structure with the ligand (holo-structure). The thesis will discuss various techniques used to determine the structural changes caused by ligand binding, including X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy. Furthermore, the thesis will provide insight into the structural and functional implications of ligand-induced conformational changes in proteins. Overall, this thesis will serve as a resource for understanding the role of ligand binding in modulating the 3D structure of proteins. Keywords: apo, holo, ligand, conformational change, IDP
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Integrální návrh v architektuře
Kohout, Lukáš
Integrated design is an approach to design that incorporates specialism in different fields that are usually considered as separate professions. Integrated design brings together methods that support specialists from different fields of design and construction. Due to the cooperation between architects, engineers, owners and users established during this process, significant cost and resources reduction in construction is achieved. Described cooperation can be often found in large architectural businesses –we can find SIAL or GAMA in Czech Republic (more specifically in Czechoslovakia); MVRDV, Behnish Architekten and Transsolar in foreign countries.
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