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Hyperkoagulační stavy u žen po in vitro fertilizaci
HODINOVÁ, Lenka
This thesis is focused on hypercoagulable states in women after the method of assisted reproduction. Pregnancy can be defined as an acquired hypercoagulable state. There are physiological changes in blood coagulation during pregnancy, and these changes can lead to a risk of thromboembolism. The occurrence of another congenital or acquired hypercoagulable state increases this risk. The aim of this thesis is to describe the differences between two groups of pregnant women, namely spontaneous pregnancy and pregnancy after in vitro fertilization. The first part of the thesis compares the differences in the incidence of hypercoagulable states. The second part of the thesis is focused on the influence of the method of conception and other monitored factors on the pregnancy outcome. For analysis were used data from the women patients´ Clinical Hematology department and the department of Neonatology in the hospital České Budějovice, a. s.
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Hyperkoagulační stavy v graviditě se zaměřením na problematiku umělého oplodnění
HODINOVÁ, Lenka
This thesis is focused on hypercoagulable states during pregnancy, especially on pregnancy after in vitro fertilisation. Hypercoagulable states are a group of congenital or acquired states that lead to the emergence deep venous thrombosis, sometimes associated with pulmonary embolism. Pregnancy itself is indicated as hypercoagulable state, which is important for facilitating hemostasis during the childbirth to avoid bleeding. It occurs to hemostatic changes during the pregnancy when there is increased concentration of most coagulation factors. The aim of this thesis is to compare coagulation laboratory results in women with spontaneous pregnancy and pregnancy after in vitro fertilisation. The results of patients were monitored in the ambulance of clinical hematology in hospital České Budějovice, a. s. in 2015 and 2016.
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Vliv vrozených hyperkoagulačních stavů na hladinu D-d se zaměřením na gravidní ženy
ŠTÍCHOVÁ, Zuzana
The thesis analyses the female patients' data from Clinical hematology department in České Budějovice hospital from year 2014 to 2015 and tries to statistically confirm connection between D-dimer level and hypercoagulable states described in previous bachelor thesis. D-dimer assay is due to negative predictive value and high sensitivity an initial laboratory test to rule out tromboembolic disease. However, it has low specificity. The elevated level of D-dimer is observed in conditions like infection, trauma, acute cancer, recent surgery or pregnancy and last studies showed increased D-dimer level even in combination with inherited hypercoagulable states. Thus, it is necessary to analyse the level of D-dimer in pregnant women related to specific hypercoagulable states. Moreover, the thesis analyses the influence of other factors like anticoagulation therapy on D-dimer level and tries to find connection between D-dimer level and pregnancy associated complication, birth weight or a type of delivery.
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Hyperkoagulační stavy v graviditě, vliv nízkomolekulárního heparinu
KABELOVÁ, Kristýna
Hypercoagulable states cause thromboembolic disease which includes deep vein thrombosis and pulmonary embolism. It's one of the most common cardiovascular diseases. It ocurrs due to genetic and acquired factors. Congenital factors include coagulation inhibitor deficiency, prothrombin gene mutation, activated protein C resistence etc. Acquired factors include use of oral contraceptives, imobility, pregnancy etc. The analytic part of the thesis is focused on level of D-dimer of pregnant women depending on congenital hypercoagulable states and anticoagulant therapy. These women were patient of Clinical hematology clinic in the České Budějovice hospital a.s. in 2016.
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Acquired hypercoagulable states focus on lupus anticoagulans
ČECHOVÁ, Magda
Hypercoagulable states (thrombophilia) can be defined as a group of inherited or aquired conditions that are associated with predisposition to venous thrombosis, arterial thrombosis or both. Inherited, but also some aquired conditions can be demonstrated by virtue of special laboratories methods. One of those methods is investigation of lupus anticoagulans, which is antibody against phospholipids. These antibodies can cause enhanced blood coagulation, which could later lead to the thrombosis. An appropriate procedure how to investigate lupus anticoagulans was defined.
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