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Hardy-Weinberg equlibrium
Vlčková, Katarína ; Zvára, Karel (advisor) ; Kulich, Michal (referee)
In this paper, we describe various tests used to determine deviations from the Hardy-Weinberg equilibrium. The tests described are: the exact test, the χ2 test with and without continuity correction, the conditional χ2 test with and without continuity correction and the likelihood ratio test. These tests explore the question whether a random sample has trinomic distribution with probabilities pAA = θ2 , pAa = 2θ(1 − θ), paa = (1 − θ)2 . In this work, we simulate data of sample size 100 and we estimate the probability of type I error and the power of the tests. In this case, we get the best results with conditional χ2 test. The estimate of the power of the likelihood ratio test and the χ2 test is one of the highest of all. On the other hand, these two test are anticonservative in some cases . 1
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Hardy-Weinberg equlibrium
Vlčková, Katarína ; Zvára, Karel (advisor) ; Kulich, Michal (referee)
In this paper, we describe various tests used to determine deviations from the Hardy-Weinberg equilibrium. The tests described are: the exact test, the χ2 test with and without continuity correction, the conditional χ2 test with and without continuity correction and the likelihood ratio test. These tests explore the question whether a random sample has trinomic distribution with probabilities pAA = θ2 , pAa = 2θ(1 − θ), paa = (1 − θ)2 . In this work, we simulate data of sample size 100 and we estimate the probability of type I error and the power of the tests. In this case, we get the best results with conditional χ2 test. The estimate of the power of the likelihood ratio test and the χ2 test is one of the highest of all. On the other hand, these two test are anticonservative in some cases . 1
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Genetic diversity in populations
Martínková, Natália ; Zemanová, Barbora
Genetic diversity accumulates over time on the level of DNA sequence with accumulation of mutations. It is additionally increased with population admixture, and the decrease in genetic diversity is often the first indication of detrimental processes affecting populations, such as reduction in the number of breeding individuals or breeding of close relatives. Nucleotide diversity shows how different the sequences of a given gene are in a population. Gene diversity estimates how likely two individuals are to share the same sequence of a gene. Number of alleles is the count of different versions of a gene with differing sequences, and this is corrected for sample size in estimation of allelic richness. Heterozygosity is the average frequency that an individual will have two different copies of a gene.
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